Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase

Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase

The enzyme TDO (tryptophan 2,3-dioxygenase; TDO-2 in Caenorhabditis elegans) is a potential therapeutic target to cancer but is also thought to regulate proteotoxic events seen in the progression of neurodegenerative diseases. To better understand its function and develop specific compounds that tar...

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Bibliographic Details
Main Authors: Michels, Helen, Seinstra, Renée I., Uitdehaag, Joost C. M., Koopman, Mandy, van Faassen, Martijn, Martineau, Céline N., Kema, Ido P., Buijsman, Rogier, Nollen, Ellen A. A.
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171515/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171515/

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