Perturbation of neddylation-dependent NF-κB responses in the intestinal epithelium drives apoptosis and inhibits resolution of mucosal inflammation

Perturbation of neddylation-dependent NF-κB responses in the intestinal epithelium drives apoptosis and inhibits resolution of mucosal inflammation

Targeting of the neddylation pathway in intestinal epithelial cells inhibits NF-κB, resulting in unabated apoptosis. These studies provide new insight into neddylation pathways within the mucosal epithelium and highlight an important role for NF-κB in the resolution of ongoing inflammation.

Bibliographic Details
Main Authors: Ehrentraut, Stefan F., Curtis, Valerie F., Wang, Ruth X., Saeedi, Bejan J., Ehrentraut, Heidi, Onyiah, Joseph C., Kelly, Caleb J., Campbell, Eric L., Glover, Louise E., Kominsky, Douglas J., Colgan, Sean P.
Format: Online
Language:English
Published: The American Society for Cell Biology 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170552/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170552/

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