Altered GABAA receptor density and unaltered blood–brain barrier [11C]flumazenil transport in drug-resistant epilepsy patients with mesial temporal sclerosis

Altered GABAA receptor density and unaltered blood–brain barrier [11C]flumazenil transport in drug-resistant epilepsy patients with mesial temporal sclerosis

Studies in rodents suggest that flumazenil is a P-glycoprotein substrate at the blood–brain barrier. This study aimed to assess whether [11C]flumazenil is a P-glycoprotein substrate in humans and to what extent increased P-glycoprotein function in epilepsy may confound interpretation of clinical [11...

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Bibliographic Details
Main Authors: Froklage, Femke E, Postnov, Andrey, Yaqub, Maqsood M, Bakker, Esther, Boellaard, Ronald, Hendrikse, N Harry, Comans, Emile FI, Schuit, Robert C, Schober, Patrick, Velis, Demetrios N, Zwemmer, Jack, Heimans, Jan J, Lammertsma, Adriaan A, Voskuyl, Rob A, Reijneveld, Jaap C
Format: Online
Language:English
Published: SAGE Publications 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167109/

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