The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer
Breast Cancer Associated gene 2 (BCA2) is an E3 ubiquitin ligase that is over-expressed in >50% of primary breast cancers, and has been shown to increase in vitro cell proliferation and invasion. The protein has been linked to alterations in EGFR degradation; however there is some dispute as to i...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Ivyspring International Publisher
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166551/ |