New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration

New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration

Skeletal muscle fibrosis and impaired muscle regeneration are major contributors to muscle wasting in Duchenne muscular dystrophy (DMD). Muscle growth is negatively regulated by myostatin (MSTN) and activins. Blockage of these pathways may improve muscle quality and function in DMD. Antisense oligon...

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Bibliographic Details
Main Authors: Pasteuning-Vuhman, Svitlana, Boertje-van der Meulen, Johanna W., van Putten, Maaike, Overzier, Maurice, ten Dijke, Peter, Kiełbasa, Szymon M., Arindrarto, Wibowo, Wolterbeek, Ron, Lezhnina, Ksenia V., Ozerov, Ivan V., Aliper, Aleksandr M., Hoogaars, Willem M., Aartsma-Rus, Annemieke, Loomans, Cindy J. M.
Format: Online
Language:English
Published: Federation of American Societies for Experimental Biology 2017
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161514/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161514/

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