Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

Cytomegalovirus (CMV) elicits long-term T-cell immunity of unparalleled strength, which has allowed the development of highly protective CMV-based vaccine vectors. Counterintuitively, experimental vaccines encoding a single MHC-I restricted epitope offered better immune protection than those express...

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Bibliographic Details
Main Authors: Dekhtiarenko, Iryna, Ratts, Robert B., Blatnik, Renata, Lee, Lian N., Fischer, Sonja, Borkner, Lisa, Oduro, Jennifer D., Marandu, Thomas F., Hoppe, Stephanie, Ruzsics, Zsolt, Sonnemann, Julia K., Mansouri, Mandana, Meyer, Christine, Lemmermann, Niels A. W., Holtappels, Rafaela, Arens, Ramon, Klenerman, Paul, Früh, Klaus, Reddehase, Matthias J., Riemer, Angelika B., Cicin-Sain, Luka
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158087/

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