Genetically manipulated phages with improved pH resistance for oral administration in veterinary medicine

Orally administered phages to control zoonotic pathogens face important challenges, mainly related to the hostile conditions found in the gastrointestinal tract (GIT). These include temperature, salinity and primarily pH, which is exceptionally low in certain compartments. Phage survival under these...

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Bibliographic Details
Main Authors: Nobrega, Franklin L., Costa, Ana Rita, Santos, José F., Siliakus, Melvin F., van Lent, Jan W. M., Kengen, Servé W. M., Azeredo, Joana, Kluskens, Leon D.
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157022/