17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

Aging is associated with visceral adiposity, metabolic disorders, and chronic low-grade inflammation. 17α-estradiol (17α-E2), a naturally occurring enantiomer of 17β-estradiol (17β-E2), extends life span in male mice through unresolved mechanisms. We tested whether 17α-E2 could alleviate age-related...

Full description

Bibliographic Details
Main Authors: Stout, Michael B., Steyn, Frederik J., Jurczak, Michael J., Camporez, Joao-Paulo G., Zhu, Yi, Hawse, John R., Jurk, Diana, Palmer, Allyson K., Xu, Ming, Pirtskhalava, Tamar, Evans, Glenda L., de Souza Santos, Roberta, Frank, Aaron P., White, Thomas A., Monroe, David G., Singh, Ravinder J., Casaclang-Verzosa, Grace, Miller, Jordan D., Clegg, Deborah J., LeBrasseur, Nathan K., von Zglinicki, Thomas, Shulman, Gerald I., Tchkonia, Tamara, Kirkland, James L.
Format: Online
Language:English
Published: Oxford University Press 2017
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155656/