Evaluation of recombinant monoclonal antibody SVmab1 binding to Na V1.7 target sequences and block of human Na V1.7 currents

Evaluation of recombinant monoclonal antibody SVmab1 binding to Na V1.7 target sequences and block of human Na V1.7 currents

Identification of small and large molecule pain therapeutics that target the genetically validated voltage-gated sodium channel Na V1.7 is a challenging endeavor under vigorous pursuit. The monoclonal antibody SVmab1 was recently published to bind the Na V1.7 DII voltage sensor domain and block huma...

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Bibliographic Details
Main Authors: Liu, Dong, Tseng, Mandy, Epstein, Linda F., Green, Lydia, Chan, Brian, Soriano, Brian, Lim, Desiree, Pan, Oscar, Murawsky, Christopher M., King, Chadwick T., Moyer, Bryan D.
Format: Online
Language:English
Published: F1000Research 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155501/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155501/

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