Electrospun poly(caprolactone)-elastin scaffolds for peripheral nerve regeneration

Peripheral nerve regeneration can be enhanced by chemical and mechanical cues for neurite growth. Aligned and randomly oriented electrospun nanofibers of poly(ε-caprolactone) (PCL) or a blend of PCL and elastin were fabricated to test their potential to provide contact guidance to embryonic chick do...

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Main Authors:	Swindle-Reilly, Katelyn E., Paranjape, Chinmay S., Miller, Cheryl A.
Format:	Online
Language:	English
Published:	Springer Berlin Heidelberg 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151100/

id	pubmed-5151100
recordtype	oai_dc
spelling	pubmed-51511002016-12-27 Electrospun poly(caprolactone)-elastin scaffolds for peripheral nerve regeneration Swindle-Reilly, Katelyn E. Paranjape, Chinmay S. Miller, Cheryl A. Original Research Peripheral nerve regeneration can be enhanced by chemical and mechanical cues for neurite growth. Aligned and randomly oriented electrospun nanofibers of poly(ε-caprolactone) (PCL) or a blend of PCL and elastin were fabricated to test their potential to provide contact guidance to embryonic chick dorsal root ganglia for peripheral nerve regeneration. Scanning electron microscopy was used to analyze the fiber diameter. Fiber diameter was found to be significantly smaller when elastin was incorporated into the scaffold (934 ± 58 nm for PCL and 519 ± 36 nm for PCL:elastin). After 24 h in culture, there was preferential cell attachment and neurite extension along the fibers of the elastin-containing scaffolds (average neurite extension 173.4 ± 20.7 μm), indicating that the presence of elastin promotes neurite outgrowth on electrospun scaffolds. Springer Berlin Heidelberg 2014-02-21 /pmc/articles/PMC5151100/ /pubmed/29470669 http://dx.doi.org/10.1007/s40204-014-0020-0 Text en © The Author(s) 2014 This article is published under license to BioMed Central Ltd. Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Swindle-Reilly, Katelyn E. Paranjape, Chinmay S. Miller, Cheryl A.
spellingShingle	Swindle-Reilly, Katelyn E. Paranjape, Chinmay S. Miller, Cheryl A. Electrospun poly(caprolactone)-elastin scaffolds for peripheral nerve regeneration
author_facet	Swindle-Reilly, Katelyn E. Paranjape, Chinmay S. Miller, Cheryl A.
author_sort	Swindle-Reilly, Katelyn E.
title	Electrospun poly(caprolactone)-elastin scaffolds for peripheral nerve regeneration
title_short	Electrospun poly(caprolactone)-elastin scaffolds for peripheral nerve regeneration
title_full	Electrospun poly(caprolactone)-elastin scaffolds for peripheral nerve regeneration
title_fullStr	Electrospun poly(caprolactone)-elastin scaffolds for peripheral nerve regeneration
title_full_unstemmed	Electrospun poly(caprolactone)-elastin scaffolds for peripheral nerve regeneration
title_sort	electrospun poly(caprolactone)-elastin scaffolds for peripheral nerve regeneration
description	Peripheral nerve regeneration can be enhanced by chemical and mechanical cues for neurite growth. Aligned and randomly oriented electrospun nanofibers of poly(ε-caprolactone) (PCL) or a blend of PCL and elastin were fabricated to test their potential to provide contact guidance to embryonic chick dorsal root ganglia for peripheral nerve regeneration. Scanning electron microscopy was used to analyze the fiber diameter. Fiber diameter was found to be significantly smaller when elastin was incorporated into the scaffold (934 ± 58 nm for PCL and 519 ± 36 nm for PCL:elastin). After 24 h in culture, there was preferential cell attachment and neurite extension along the fibers of the elastin-containing scaffolds (average neurite extension 173.4 ± 20.7 μm), indicating that the presence of elastin promotes neurite outgrowth on electrospun scaffolds.
publisher	Springer Berlin Heidelberg
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151100/
_version_	1613774565331173376

Electrospun poly(caprolactone)-elastin scaffolds for peripheral nerve regeneration

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