Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis

The association between neutrophil-to-lymphocyte ratio (NLR) and differentiated thyroid cancer (DTC) is undecided. To rectify this question, we conducted a systematic meta-analysis based on 7 prospective cohort studies published between 2013 and 2015, comprising 7349 patients. Six of these cohorts i...

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Main Authors:	Liu, Ji-Feng, Ba, Luo, Lv, Hong, Lv, Dan, Du, Jin-Tao, Jing, Xiao-Mei, Yang, Ning-Jing, Wang, Shao-Xin, Li, Chao, Li, Xiao-Xia
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150572/

id	pubmed-5150572
recordtype	oai_dc
spelling	pubmed-51505722016-12-19 Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis Liu, Ji-Feng Ba, Luo Lv, Hong Lv, Dan Du, Jin-Tao Jing, Xiao-Mei Yang, Ning-Jing Wang, Shao-Xin Li, Chao Li, Xiao-Xia Article The association between neutrophil-to-lymphocyte ratio (NLR) and differentiated thyroid cancer (DTC) is undecided. To rectify this question, we conducted a systematic meta-analysis based on 7 prospective cohort studies published between 2013 and 2015, comprising 7349 patients. Six of these cohorts included pretreatment (baseline) NLR data for patients with thyroid nodules. The meta-analysis of these 6 cohorts showed that the NLR of patients with DTC (4617 cases) was statistically similar to patients with benign nodules only (1666 cases), with a mean difference (MD) of 0.19 (95% CI: −0.09 to 0.46; I2 = 93%; P < 0.001). No significant difference in NLR was found between patients with DTC and patients with benign nodules. Two studies addressed an association between NLR and papillary thyroid carcinoma in patients stratified by age <45 and ≥45 years (496 and 891 cases, respectively); the pooled MD was 0.09 (95% CI: −0.37 to 0.55; I2 = 92.2%, P < 0.001). An elevated NLR seems not a reliable indicator of progressing DTC in patients with goiters, and there was no difference in NLR between patients aged <45 years and those aged ≥45 years. Well-designed and large-scale investigations are warranted to understand the value of NLR in the prognosis of DTC. Nature Publishing Group 2016-12-12 /pmc/articles/PMC5150572/ /pubmed/27941815 http://dx.doi.org/10.1038/srep38551 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Liu, Ji-Feng Ba, Luo Lv, Hong Lv, Dan Du, Jin-Tao Jing, Xiao-Mei Yang, Ning-Jing Wang, Shao-Xin Li, Chao Li, Xiao-Xia
spellingShingle	Liu, Ji-Feng Ba, Luo Lv, Hong Lv, Dan Du, Jin-Tao Jing, Xiao-Mei Yang, Ning-Jing Wang, Shao-Xin Li, Chao Li, Xiao-Xia Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis
author_facet	Liu, Ji-Feng Ba, Luo Lv, Hong Lv, Dan Du, Jin-Tao Jing, Xiao-Mei Yang, Ning-Jing Wang, Shao-Xin Li, Chao Li, Xiao-Xia
author_sort	Liu, Ji-Feng
title	Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis
title_short	Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis
title_full	Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis
title_fullStr	Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis
title_full_unstemmed	Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis
title_sort	association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis
description	The association between neutrophil-to-lymphocyte ratio (NLR) and differentiated thyroid cancer (DTC) is undecided. To rectify this question, we conducted a systematic meta-analysis based on 7 prospective cohort studies published between 2013 and 2015, comprising 7349 patients. Six of these cohorts included pretreatment (baseline) NLR data for patients with thyroid nodules. The meta-analysis of these 6 cohorts showed that the NLR of patients with DTC (4617 cases) was statistically similar to patients with benign nodules only (1666 cases), with a mean difference (MD) of 0.19 (95% CI: −0.09 to 0.46; I2 = 93%; P < 0.001). No significant difference in NLR was found between patients with DTC and patients with benign nodules. Two studies addressed an association between NLR and papillary thyroid carcinoma in patients stratified by age <45 and ≥45 years (496 and 891 cases, respectively); the pooled MD was 0.09 (95% CI: −0.37 to 0.55; I2 = 92.2%, P < 0.001). An elevated NLR seems not a reliable indicator of progressing DTC in patients with goiters, and there was no difference in NLR between patients aged <45 years and those aged ≥45 years. Well-designed and large-scale investigations are warranted to understand the value of NLR in the prognosis of DTC.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150572/
_version_	1613773810686754816

Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis

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