Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders

In order to combat chronic immune disorders (CIDs), it is an absolute necessity to understand the bigger picture, one that goes beyond insights at a one-disease, molecular, cellular, and static level. To unravel this bigger picture we advocate an integral, cross-disciplinary approach capable of embr...

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Main Authors:	te Velde, Anje A., Bezema, Tjitske, van Kampen, Antoine H. C., Kraneveld, Aletta D., 't Hart, Bert A., van Middendorp, Henriët, Hack, Erik C., van Montfrans, Joris M., Belzer, Clara, Jans-Beken, Lilian, Pieters, Raymond H., Knipping, Karen, Huber, Machteld, Boots, Annemieke M. H., Garssen, Johan, Radstake, Tim R., Evers, Andrea W. M., Prakken, Berent J., Joosten, Irma
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149516/

id	pubmed-5149516
recordtype	oai_dc
spelling	pubmed-51495162016-12-23 Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders te Velde, Anje A. Bezema, Tjitske van Kampen, Antoine H. C. Kraneveld, Aletta D. 't Hart, Bert A. van Middendorp, Henriët Hack, Erik C. van Montfrans, Joris M. Belzer, Clara Jans-Beken, Lilian Pieters, Raymond H. Knipping, Karen Huber, Machteld Boots, Annemieke M. H. Garssen, Johan Radstake, Tim R. Evers, Andrea W. M. Prakken, Berent J. Joosten, Irma Immunology In order to combat chronic immune disorders (CIDs), it is an absolute necessity to understand the bigger picture, one that goes beyond insights at a one-disease, molecular, cellular, and static level. To unravel this bigger picture we advocate an integral, cross-disciplinary approach capable of embracing the complexity of the field. This paper discusses the current knowledge on common pathways in CIDs including general psychosocial and lifestyle factors associated with immune functioning. We demonstrate the lack of more in-depth psychosocial and lifestyle factors in current research cohorts and most importantly the need for an all-encompassing analysis of these factors. The second part of the paper discusses the challenges of understanding immune system dynamics and effectively integrating all key perspectives on immune functioning, including the patient’s perspective itself. This paper suggests the use of techniques from complex systems science in describing and simulating healthy or deviating behavior of the immune system in its biopsychosocial surroundings. The patient’s perspective data are suggested to be generated by using specific narrative techniques. We conclude that to gain more insight into the behavior of the whole system and to acquire new ways of combatting CIDs, we need to construct and apply new techniques in the field of computational and complexity science, to an even wider variety of dynamic data than used in today’s systems medicine. Frontiers Media S.A. 2016-12-12 /pmc/articles/PMC5149516/ /pubmed/28018353 http://dx.doi.org/10.3389/fimmu.2016.00587 Text en Copyright © 2016 te Velde, Bezema, van Kampen, Kraneveld, 't Hart, van Middendorp, Hack, van Montfrans, Belzer, Jans-Beken, Pieters, Knipping, Huber, Boots, Garssen, Radstake, Evers, Prakken and Joosten. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	te Velde, Anje A. Bezema, Tjitske van Kampen, Antoine H. C. Kraneveld, Aletta D. 't Hart, Bert A. van Middendorp, Henriët Hack, Erik C. van Montfrans, Joris M. Belzer, Clara Jans-Beken, Lilian Pieters, Raymond H. Knipping, Karen Huber, Machteld Boots, Annemieke M. H. Garssen, Johan Radstake, Tim R. Evers, Andrea W. M. Prakken, Berent J. Joosten, Irma
spellingShingle	te Velde, Anje A. Bezema, Tjitske van Kampen, Antoine H. C. Kraneveld, Aletta D. 't Hart, Bert A. van Middendorp, Henriët Hack, Erik C. van Montfrans, Joris M. Belzer, Clara Jans-Beken, Lilian Pieters, Raymond H. Knipping, Karen Huber, Machteld Boots, Annemieke M. H. Garssen, Johan Radstake, Tim R. Evers, Andrea W. M. Prakken, Berent J. Joosten, Irma Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders
author_facet	te Velde, Anje A. Bezema, Tjitske van Kampen, Antoine H. C. Kraneveld, Aletta D. 't Hart, Bert A. van Middendorp, Henriët Hack, Erik C. van Montfrans, Joris M. Belzer, Clara Jans-Beken, Lilian Pieters, Raymond H. Knipping, Karen Huber, Machteld Boots, Annemieke M. H. Garssen, Johan Radstake, Tim R. Evers, Andrea W. M. Prakken, Berent J. Joosten, Irma
author_sort	te Velde, Anje A.
title	Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders
title_short	Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders
title_full	Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders
title_fullStr	Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders
title_full_unstemmed	Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders
title_sort	embracing complexity beyond systems medicine: a new approach to chronic immune disorders
description	In order to combat chronic immune disorders (CIDs), it is an absolute necessity to understand the bigger picture, one that goes beyond insights at a one-disease, molecular, cellular, and static level. To unravel this bigger picture we advocate an integral, cross-disciplinary approach capable of embracing the complexity of the field. This paper discusses the current knowledge on common pathways in CIDs including general psychosocial and lifestyle factors associated with immune functioning. We demonstrate the lack of more in-depth psychosocial and lifestyle factors in current research cohorts and most importantly the need for an all-encompassing analysis of these factors. The second part of the paper discusses the challenges of understanding immune system dynamics and effectively integrating all key perspectives on immune functioning, including the patient’s perspective itself. This paper suggests the use of techniques from complex systems science in describing and simulating healthy or deviating behavior of the immune system in its biopsychosocial surroundings. The patient’s perspective data are suggested to be generated by using specific narrative techniques. We conclude that to gain more insight into the behavior of the whole system and to acquire new ways of combatting CIDs, we need to construct and apply new techniques in the field of computational and complexity science, to an even wider variety of dynamic data than used in today’s systems medicine.
publisher	Frontiers Media S.A.
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149516/
_version_	1613772294248726528

Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders

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