Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization

Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization

Most studies of the mechanisms leading to hereditary dilated cardiomyopathy (DCM) have been performed in reconstituted in vitro systems. Genetically engineered murine models offer the opportunity to dissect these mechanisms in vivo. We generated a gene-targeted knock-in murine model of the autosomal...

Full description

Bibliographic Details
Main Authors: Ramratnam, Mohun, Salama, Guy, Sharma, Ravi K., Wang, David Wen Rui, Smith, Stephen H., Banerjee, Sanjay K., Huang, Xueyin N., Gifford, Lindsey M., Pruce, Michele L., Gabris, Bethann E., Saba, Samir, Shroff, Sanjeev G., Ahmad, Ferhaan
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147943/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147943/

Similar Items