Antioxidant defense in Plasmodium falciparum – data mining of the transcriptome
The intraerythrocytic malaria parasite is under constant oxidative stress originating both from endogenous and exogenous processes. The parasite is endowed with a complete network of enzymes and proteins that protect it from those threats, but also uses redox activities to regulate enzyme activities...
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| Format: | Online |
| Language: | English |
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BioMed Central
2004
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514526/ |
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pubmed-5145262004-08-25 Antioxidant defense in Plasmodium falciparum – data mining of the transcriptome Bozdech, Zbynek Ginsburg, Hagai Research The intraerythrocytic malaria parasite is under constant oxidative stress originating both from endogenous and exogenous processes. The parasite is endowed with a complete network of enzymes and proteins that protect it from those threats, but also uses redox activities to regulate enzyme activities. In the present analysis, the transcription of the genes coding for the antioxidant defense elements are viewed in the time-frame of the intraerythrocytic cycle. Time-dependent transcription data were taken from the transcriptome of the human malaria parasite Plasmodium falciparum. Whereas for several processes the transcription of the many participating genes is coordinated, in the present case there are some outstanding deviations where gene products that utilize glutathione or thioredoxin are transcribed before the genes coding for elements that control the levels of those substrates are transcribed. Such insights may hint to novel, non-classical pathways that necessitate further investigations. BioMed Central 2004-07-09 /pmc/articles/PMC514526/ /pubmed/15245577 http://dx.doi.org/10.1186/1475-2875-3-23 Text en Copyright © 2004 Bozdech and Ginsburg; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Bozdech, Zbynek Ginsburg, Hagai |
| spellingShingle |
Bozdech, Zbynek Ginsburg, Hagai Antioxidant defense in Plasmodium falciparum – data mining of the transcriptome |
| author_facet |
Bozdech, Zbynek Ginsburg, Hagai |
| author_sort |
Bozdech, Zbynek |
| title |
Antioxidant defense in Plasmodium falciparum – data mining of the transcriptome |
| title_short |
Antioxidant defense in Plasmodium falciparum – data mining of the transcriptome |
| title_full |
Antioxidant defense in Plasmodium falciparum – data mining of the transcriptome |
| title_fullStr |
Antioxidant defense in Plasmodium falciparum – data mining of the transcriptome |
| title_full_unstemmed |
Antioxidant defense in Plasmodium falciparum – data mining of the transcriptome |
| title_sort |
antioxidant defense in plasmodium falciparum – data mining of the transcriptome |
| description |
The intraerythrocytic malaria parasite is under constant oxidative stress originating both from endogenous and exogenous processes. The parasite is endowed with a complete network of enzymes and proteins that protect it from those threats, but also uses redox activities to regulate enzyme activities. In the present analysis, the transcription of the genes coding for the antioxidant defense elements are viewed in the time-frame of the intraerythrocytic cycle. Time-dependent transcription data were taken from the transcriptome of the human malaria parasite Plasmodium falciparum. Whereas for several processes the transcription of the many participating genes is coordinated, in the present case there are some outstanding deviations where gene products that utilize glutathione or thioredoxin are transcribed before the genes coding for elements that control the levels of those substrates are transcribed. Such insights may hint to novel, non-classical pathways that necessitate further investigations. |
| publisher |
BioMed Central |
| publishDate |
2004 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514526/ |
| _version_ |
1611369275335901184 |