The Ebola Interferon Inhibiting Domains Attenuate and Dysregulate Cell-Mediated Immune Responses

The Ebola Interferon Inhibiting Domains Attenuate and Dysregulate Cell-Mediated Immune Responses

Ebola virus (EBOV) infections are characterized by deficient T-lymphocyte responses, T-lymphocyte apoptosis and lymphopenia. We previously showed that disabling of interferon-inhibiting domains (IIDs) in the VP24 and VP35 proteins effectively unblocks maturation of dendritic cells (DCs) and increase...

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Bibliographic Details
Main Authors: Lubaki, Ndongala Michel, Younan, Patrick, Santos, Rodrigo I., Meyer, Michelle, Iampietro, Mathieu, Koup, Richard A., Bukreyev, Alexander
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145241/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145241/

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