The Rab5 Effector Rabankyrin-5 Regulates and Coordinates Different Endocytic Mechanisms

The small GTPase Rab5 is a key regulator of clathrin-mediated endocytosis. On early endosomes, within a spatially restricted domain enriched in phosphatydilinositol-3-phosphate [PI(3)P], Rab5 coordinates a complex network of effectors that functionally cooperate in membrane tethering, fusion, and or...

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Bibliographic Details
Main Authors: Schnatwinkel, Carsten, Christoforidis, Savvas, Lindsay, Margaret R, Uttenweiler-Joseph, Sandrine, Wilm, Matthias, Parton, Robert G, Zerial, Marino
Format: Online
Language:English
Published: Public Library of Science 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514490/