Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel

Mesoporous silica nanoparticles (MSNs) are known as carriers with high loading capacity and large functionalizable surface area for target-directed delivery. In this study, a series of docetaxel-loaded folic acid- or methionine-functionalized mesoporous silica nanoparticles (DTX/MSN-FA or DTX/MSN-Me...

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Main Authors:	Khosravian, Pegah, Shafiee Ardestani, Mehdi, Khoobi, Mehdi, Ostad, Seyed Naser, Dorkoosh, Farid Abedin, Akbari Javar, Hamid, Amanlou, Massoud
Format:	Online
Language:	English
Published:	Dove Medical Press 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144897/

id	pubmed-5144897
recordtype	oai_dc
spelling	pubmed-51448972016-12-15 Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel Khosravian, Pegah Shafiee Ardestani, Mehdi Khoobi, Mehdi Ostad, Seyed Naser Dorkoosh, Farid Abedin Akbari Javar, Hamid Amanlou, Massoud Original Research Mesoporous silica nanoparticles (MSNs) are known as carriers with high loading capacity and large functionalizable surface area for target-directed delivery. In this study, a series of docetaxel-loaded folic acid- or methionine-functionalized mesoporous silica nanoparticles (DTX/MSN-FA or DTX/MSN-Met) with large pores and amine groups at inner pore surface properties were prepared. The results showed that the MSNs were successfully synthesized, having good pay load and pH-sensitive drug release kinetics. The cellular investigation on MCF-7 cells showed better performance of cytotoxicity and cell apoptosis and an increase in cellular uptake of targeted nanoparticles. In vivo fluorescent imaging on healthy BALB/c mice proved that bare MSN-NH2 are mostly accumulated in the liver but MSN-FA or MSN-Met are more concentrated in the kidney. Importantly, ex vivo fluorescent images of tumor-induced BALB/c mice organs revealed the ability of MSN-FA to reach the tumor tissues. In conclusion, DTX/MSNs exhibited a good anticancer activity and enhanced the possibility of targeted drug delivery for breast cancer. Dove Medical Press 2016-12-01 /pmc/articles/PMC5144897/ /pubmed/27980423 http://dx.doi.org/10.2147/OTT.S113815 Text en © 2016 Pegah et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Khosravian, Pegah Shafiee Ardestani, Mehdi Khoobi, Mehdi Ostad, Seyed Naser Dorkoosh, Farid Abedin Akbari Javar, Hamid Amanlou, Massoud
spellingShingle	Khosravian, Pegah Shafiee Ardestani, Mehdi Khoobi, Mehdi Ostad, Seyed Naser Dorkoosh, Farid Abedin Akbari Javar, Hamid Amanlou, Massoud Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel
author_facet	Khosravian, Pegah Shafiee Ardestani, Mehdi Khoobi, Mehdi Ostad, Seyed Naser Dorkoosh, Farid Abedin Akbari Javar, Hamid Amanlou, Massoud
author_sort	Khosravian, Pegah
title	Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel
title_short	Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel
title_full	Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel
title_fullStr	Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel
title_full_unstemmed	Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel
title_sort	mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel
description	Mesoporous silica nanoparticles (MSNs) are known as carriers with high loading capacity and large functionalizable surface area for target-directed delivery. In this study, a series of docetaxel-loaded folic acid- or methionine-functionalized mesoporous silica nanoparticles (DTX/MSN-FA or DTX/MSN-Met) with large pores and amine groups at inner pore surface properties were prepared. The results showed that the MSNs were successfully synthesized, having good pay load and pH-sensitive drug release kinetics. The cellular investigation on MCF-7 cells showed better performance of cytotoxicity and cell apoptosis and an increase in cellular uptake of targeted nanoparticles. In vivo fluorescent imaging on healthy BALB/c mice proved that bare MSN-NH2 are mostly accumulated in the liver but MSN-FA or MSN-Met are more concentrated in the kidney. Importantly, ex vivo fluorescent images of tumor-induced BALB/c mice organs revealed the ability of MSN-FA to reach the tumor tissues. In conclusion, DTX/MSNs exhibited a good anticancer activity and enhanced the possibility of targeted drug delivery for breast cancer.
publisher	Dove Medical Press
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144897/
_version_	1613766266773831680

Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel

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