The known genetic loci for telomere length may be involved in the modification of telomeres length after birth

Telomere length varies considerably among individuals. It is highly heritable and decreases with ageing or ageing related diseases. Recently, genome-wide association studies (GWAS) have identified several genetic loci associated with telomere length in adults. However, it is unclear whether these lo...

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Main Authors:	Weng, Qiao, Du, Jiangbo, Yu, Fei, Huang, Tongtong, Chen, Mengxi, Lv, Hong, Ma, Hongxia, Hu, Zhibin, Jin, Guangfu, Hu, Yali, Shen, Hongbing
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143977/

id	pubmed-5143977
recordtype	oai_dc
spelling	pubmed-51439772016-12-16 The known genetic loci for telomere length may be involved in the modification of telomeres length after birth Weng, Qiao Du, Jiangbo Yu, Fei Huang, Tongtong Chen, Mengxi Lv, Hong Ma, Hongxia Hu, Zhibin Jin, Guangfu Hu, Yali Shen, Hongbing Article Telomere length varies considerably among individuals. It is highly heritable and decreases with ageing or ageing related diseases. Recently, genome-wide association studies (GWAS) have identified several genetic loci associated with telomere length in adults. However, it is unclear whether these loci represent the genetic basis of telomere length or determine the individual susceptibility to shortening during growth process. Using DNA extracted from peripheral and cord blood of 444 mother-newborn pairs from a Chinese population, we measured relative telomere length (RTL) and genotyped eight known telomere length related variants that were initially identified in populations of European descent. We observed the T allele of rs10936599 and the T allele of rs2736100 were norminally associated with shorter RTL (P = 0.041 and 0.046, respectively) in maternal samples. Furthermore, the Weighted genetic score (WGS) of eight variants was significantly associated with RTL in maternal samples (R2 = 0.012, P = 0.025). However, we didn’t detect any significant associations for any individual variant or the combined WGS with RTL in newborns. These findings didn’t support the hypothesis that telomere length related loci may affect telomere length at birth, and we suggested that these loci may play a role in telomere length modification during life course. Nature Publishing Group 2016-12-08 /pmc/articles/PMC5143977/ /pubmed/27929092 http://dx.doi.org/10.1038/srep38729 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Weng, Qiao Du, Jiangbo Yu, Fei Huang, Tongtong Chen, Mengxi Lv, Hong Ma, Hongxia Hu, Zhibin Jin, Guangfu Hu, Yali Shen, Hongbing
spellingShingle	Weng, Qiao Du, Jiangbo Yu, Fei Huang, Tongtong Chen, Mengxi Lv, Hong Ma, Hongxia Hu, Zhibin Jin, Guangfu Hu, Yali Shen, Hongbing The known genetic loci for telomere length may be involved in the modification of telomeres length after birth
author_facet	Weng, Qiao Du, Jiangbo Yu, Fei Huang, Tongtong Chen, Mengxi Lv, Hong Ma, Hongxia Hu, Zhibin Jin, Guangfu Hu, Yali Shen, Hongbing
author_sort	Weng, Qiao
title	The known genetic loci for telomere length may be involved in the modification of telomeres length after birth
title_short	The known genetic loci for telomere length may be involved in the modification of telomeres length after birth
title_full	The known genetic loci for telomere length may be involved in the modification of telomeres length after birth
title_fullStr	The known genetic loci for telomere length may be involved in the modification of telomeres length after birth
title_full_unstemmed	The known genetic loci for telomere length may be involved in the modification of telomeres length after birth
title_sort	known genetic loci for telomere length may be involved in the modification of telomeres length after birth
description	Telomere length varies considerably among individuals. It is highly heritable and decreases with ageing or ageing related diseases. Recently, genome-wide association studies (GWAS) have identified several genetic loci associated with telomere length in adults. However, it is unclear whether these loci represent the genetic basis of telomere length or determine the individual susceptibility to shortening during growth process. Using DNA extracted from peripheral and cord blood of 444 mother-newborn pairs from a Chinese population, we measured relative telomere length (RTL) and genotyped eight known telomere length related variants that were initially identified in populations of European descent. We observed the T allele of rs10936599 and the T allele of rs2736100 were norminally associated with shorter RTL (P = 0.041 and 0.046, respectively) in maternal samples. Furthermore, the Weighted genetic score (WGS) of eight variants was significantly associated with RTL in maternal samples (R2 = 0.012, P = 0.025). However, we didn’t detect any significant associations for any individual variant or the combined WGS with RTL in newborns. These findings didn’t support the hypothesis that telomere length related loci may affect telomere length at birth, and we suggested that these loci may play a role in telomere length modification during life course.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143977/
_version_	1613765060906188800

The known genetic loci for telomere length may be involved in the modification of telomeres length after birth

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