Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9

Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9

The capacity of certain adeno-associated virus (AAV) vectors to cross the blood–brain barrier after intravenous delivery offers a unique opportunity for noninvasive brain delivery. However, without a well-tailored system, the use of a peripheral route injection may lead to undesirable transgene expr...

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Bibliographic Details
Main Authors: Dashkoff, Jonathan, Lerner, Eli P, Truong, Nhi, Klickstein, Jacob A, Fan, Zhanyun, Mu, Dakai, Maguire, Casey A, Hyman, Bradley T, Hudry, Eloise
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142512/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142512/

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