PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

Activin receptor-like kinase 1 (ALK1) is an endothelial serine–threonine kinase receptor for bone morphogenetic proteins (BMPs) 9 and 10. Inactivating mutations in the ALK1 gene cause hereditary haemorrhagic telangiectasia type 2 (HHT2), a disabling disease characterized by excessive angiogenesis wi...

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Bibliographic Details
Main Authors: Ola, Roxana, Dubrac, Alexandre, Han, Jinah, Zhang, Feng, Fang, Jennifer S., Larrivée, Bruno, Lee, Monica, Urarte, Ana A., Kraehling, Jan R., Genet, Gael, Hirschi, Karen K., Sessa, William C., Canals, Francesc V., Graupera, Mariona, Yan, Minhong, Young, Lawrence H., Oh, Paul S., Eichmann, Anne
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141347/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141347/

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