Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older
This study investigated whether high-normal thyrotropin (TSH) levels are associated with metabolic syndrome in euthyroid Chinese people≥40 years old. Clinical and metabolic factors were assessed in 2,356 subjects (40–77 years old) with TSH levels in the normal range (0.35–5.00 mU/L). Using 2.50 mU/L...
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Editorial Department of Journal of Biomedical Research
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138579/ |
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pubmed-51385792016-12-16 Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older Xu, Bojin Yang, Hui Wang, Zhixiao Yang, Tao Guo, Hongwei Cheng, Pei He, Wei Sun, Min Chen, Huanhuan Duan, Yu Original Article This study investigated whether high-normal thyrotropin (TSH) levels are associated with metabolic syndrome in euthyroid Chinese people≥40 years old. Clinical and metabolic factors were assessed in 2,356 subjects (40–77 years old) with TSH levels in the normal range (0.35–5.00 mU/L). Using 2.50 mU/L as the cut-off point of TSH level within the normal range, we divided subjects into the high-TSH (2.50–5.00 mU/L; n = 1,064) and low-TSH (0.35–2.50 mU/L; n = 1,292) group. The results showed that the mean levels of body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and fasting plasma glucose (FPG) were higher in the high-TSH group and TSH levels were significantly positively correlated with BMI, LDL-C, TC, and FPG. The prevalence of central obesity, hypertriglyceridemia, low high density lipoprotein cholesterol (HDL-C), and high FPG (>5.60 mmol/L) was significantly higher in females and subjects with high-TSH levels. Metabolic syndrome was also more prevalent in the high-TSH group. People over the age of 40 years with high-normal TSH levels had a 1.2-fold increased risk of metabolic syndrome, compared with those with low-normal TSH levels, after adjusting for age and gender. In conclusion, high normal TSH is a risk factor for metabolic syndrome in people≥40 years old. Editorial Department of Journal of Biomedical Research 2016-11 2016-05-20 /pmc/articles/PMC5138579/ /pubmed/27760888 http://dx.doi.org/10.7555/JBR.30.20150103 Text en © 2016 by the Journal of Biomedical Research. All rights reserved. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Xu, Bojin Yang, Hui Wang, Zhixiao Yang, Tao Guo, Hongwei Cheng, Pei He, Wei Sun, Min Chen, Huanhuan Duan, Yu |
| spellingShingle |
Xu, Bojin Yang, Hui Wang, Zhixiao Yang, Tao Guo, Hongwei Cheng, Pei He, Wei Sun, Min Chen, Huanhuan Duan, Yu Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older |
| author_facet |
Xu, Bojin Yang, Hui Wang, Zhixiao Yang, Tao Guo, Hongwei Cheng, Pei He, Wei Sun, Min Chen, Huanhuan Duan, Yu |
| author_sort |
Xu, Bojin |
| title |
Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older |
| title_short |
Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older |
| title_full |
Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older |
| title_fullStr |
Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older |
| title_full_unstemmed |
Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older |
| title_sort |
elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a chinese community-based population of euthyroid people aged 40 years and older |
| description |
This study investigated whether high-normal thyrotropin (TSH) levels are associated with metabolic syndrome in euthyroid Chinese people≥40 years old. Clinical and metabolic factors were assessed in 2,356 subjects (40–77 years old) with TSH levels in the normal range (0.35–5.00 mU/L). Using 2.50 mU/L as the cut-off point of TSH level within the normal range, we divided subjects into the high-TSH (2.50–5.00 mU/L; n = 1,064) and low-TSH (0.35–2.50 mU/L; n = 1,292) group. The results showed that the mean levels of body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and fasting plasma glucose (FPG) were higher in the high-TSH group and TSH levels were significantly positively correlated with BMI, LDL-C, TC, and FPG. The prevalence of central obesity, hypertriglyceridemia, low high density lipoprotein cholesterol (HDL-C), and high FPG (>5.60 mmol/L) was significantly higher in females and subjects with high-TSH levels. Metabolic syndrome was also more prevalent in the high-TSH group. People over the age of 40 years with high-normal TSH levels had a 1.2-fold increased risk of metabolic syndrome, compared with those with low-normal TSH levels, after adjusting for age and gender. In conclusion, high normal TSH is a risk factor for metabolic syndrome in people≥40 years old. |
| publisher |
Editorial Department of Journal of Biomedical Research |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138579/ |
| _version_ |
1613758210616852480 |