Extracellular vesicle-associated Aβ mediates trans-neuronal bioenergetic and Ca2+-handling deficits in Alzheimer’s disease models

Extracellular vesicle-associated Aβ mediates trans-neuronal bioenergetic and Ca2+-handling deficits in Alzheimer’s disease models

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder in which aggregation-prone neurotoxic amyloid β-peptide (Aβ) accumulates in the brain. Extracellular vesicles (EVs), including exosomes, are small 50–150 nm membrane vesicles that have recently been implicated in the prion-like sp...

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Bibliographic Details
Main Authors: Eitan, Erez, Hutchison, Emmette R, Marosi, Krisztina, Comotto, James, Mustapic, Maja, Nigam, Saket M, Suire, Caitlin, Maharana, Chinmoyee, Jicha, Gregory A, Liu, Dong, Machairaki, Vasiliki, Witwer, Kenneth W, Kapogiannis, Dimitrios, Mattson, Mark P
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137253/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137253/

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