Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators

The fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was...

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Main Authors:	Santos, Vinicius Coneglian, Sierra, Ana Paula Renno, Oliveira, Rodrigo, Caçula, Kim Guimarães, Momesso, César Miguel, Sato, Fabio Takeo, Silva, Maysa Braga Barros, Oliveira, Heloisa Helena, Passos, Maria Elizabeth Pereira, de Souza, Diego Ribeiro, Gondim, Olivia Santos, Benetti, Marino, Levada-Pires, Adriana Cristina, Ghorayeb, Nabil, Kiss, Maria Augusta Peduti Dal Molin, Gorjão, Renata, Pithon-Curi, Tânia Cristina, Cury-Boaventura, Maria Fernanda
Format:	Online
Language:	English
Published:	Public Library of Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135050/

id	pubmed-5135050
recordtype	oai_dc
spelling	pubmed-51350502016-12-21 Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators Santos, Vinicius Coneglian Sierra, Ana Paula Renno Oliveira, Rodrigo Caçula, Kim Guimarães Momesso, César Miguel Sato, Fabio Takeo Silva, Maysa Braga Barros Oliveira, Heloisa Helena Passos, Maria Elizabeth Pereira de Souza, Diego Ribeiro Gondim, Olivia Santos Benetti, Marino Levada-Pires, Adriana Cristina Ghorayeb, Nabil Kiss, Maria Augusta Peduti Dal Molin Gorjão, Renata Pithon-Curi, Tânia Cristina Cury-Boaventura, Maria Fernanda Research Article The fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was to investigate the effect of marathon races on surface molecules related to neutrophil adhesion and extrinsic apoptosis pathway and its association with inflammatory markers. We evaluated 23 trained male runners at the São Paulo International Marathon 2013. The following components were measured: hematological and inflammatory mediators, muscle damage markers, and neutrophil function. The marathon race induced an increased leukocyte and neutrophil counts; creatine kinase (CK), lactate dehydrogenase (LDH), CK-MB, interleukin (IL)-6, IL-10, and IL-8 levels. C-reactive protein (CRP), IL-12, and tumor necrosis factor (TNF)-α plasma concentrations were significantly higher 24 h and 72 h after the marathon race. Hemoglobin and hematocrit levels decreased 72 h after the marathon race. We also observed an increased intercellular adhesion molecule-1 (ICAM-1) expression and decreasedTNF receptor-1 (TNFR1) expression immediately after and 24 h after the marathon race. We observed an increased DNA fragmentation and L-selectin and Fas receptor expressions in the recovery period, indicating a possible slow rolling phase and delayed neutrophil activation and apoptosis. Marathon racing affects neutrophils adhesion and survival in the course of inflammation, supporting the “open-window” post-exercise hypothesis. Public Library of Science 2016-12-02 /pmc/articles/PMC5135050/ /pubmed/27911915 http://dx.doi.org/10.1371/journal.pone.0166687 Text en © 2016 Santos et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Santos, Vinicius Coneglian Sierra, Ana Paula Renno Oliveira, Rodrigo Caçula, Kim Guimarães Momesso, César Miguel Sato, Fabio Takeo Silva, Maysa Braga Barros Oliveira, Heloisa Helena Passos, Maria Elizabeth Pereira de Souza, Diego Ribeiro Gondim, Olivia Santos Benetti, Marino Levada-Pires, Adriana Cristina Ghorayeb, Nabil Kiss, Maria Augusta Peduti Dal Molin Gorjão, Renata Pithon-Curi, Tânia Cristina Cury-Boaventura, Maria Fernanda
spellingShingle	Santos, Vinicius Coneglian Sierra, Ana Paula Renno Oliveira, Rodrigo Caçula, Kim Guimarães Momesso, César Miguel Sato, Fabio Takeo Silva, Maysa Braga Barros Oliveira, Heloisa Helena Passos, Maria Elizabeth Pereira de Souza, Diego Ribeiro Gondim, Olivia Santos Benetti, Marino Levada-Pires, Adriana Cristina Ghorayeb, Nabil Kiss, Maria Augusta Peduti Dal Molin Gorjão, Renata Pithon-Curi, Tânia Cristina Cury-Boaventura, Maria Fernanda Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators
author_facet	Santos, Vinicius Coneglian Sierra, Ana Paula Renno Oliveira, Rodrigo Caçula, Kim Guimarães Momesso, César Miguel Sato, Fabio Takeo Silva, Maysa Braga Barros Oliveira, Heloisa Helena Passos, Maria Elizabeth Pereira de Souza, Diego Ribeiro Gondim, Olivia Santos Benetti, Marino Levada-Pires, Adriana Cristina Ghorayeb, Nabil Kiss, Maria Augusta Peduti Dal Molin Gorjão, Renata Pithon-Curi, Tânia Cristina Cury-Boaventura, Maria Fernanda
author_sort	Santos, Vinicius Coneglian
title	Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators
title_short	Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators
title_full	Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators
title_fullStr	Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators
title_full_unstemmed	Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators
title_sort	marathon race affects neutrophil surface molecules: role of inflammatory mediators
description	The fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was to investigate the effect of marathon races on surface molecules related to neutrophil adhesion and extrinsic apoptosis pathway and its association with inflammatory markers. We evaluated 23 trained male runners at the São Paulo International Marathon 2013. The following components were measured: hematological and inflammatory mediators, muscle damage markers, and neutrophil function. The marathon race induced an increased leukocyte and neutrophil counts; creatine kinase (CK), lactate dehydrogenase (LDH), CK-MB, interleukin (IL)-6, IL-10, and IL-8 levels. C-reactive protein (CRP), IL-12, and tumor necrosis factor (TNF)-α plasma concentrations were significantly higher 24 h and 72 h after the marathon race. Hemoglobin and hematocrit levels decreased 72 h after the marathon race. We also observed an increased intercellular adhesion molecule-1 (ICAM-1) expression and decreasedTNF receptor-1 (TNFR1) expression immediately after and 24 h after the marathon race. We observed an increased DNA fragmentation and L-selectin and Fas receptor expressions in the recovery period, indicating a possible slow rolling phase and delayed neutrophil activation and apoptosis. Marathon racing affects neutrophils adhesion and survival in the course of inflammation, supporting the “open-window” post-exercise hypothesis.
publisher	Public Library of Science
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135050/
_version_	1613754561395163136

Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators

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