Comparison of the Estimated Incidence of Acute Leptospirosis in the Kilimanjaro Region of Tanzania between 2007–08 and 2012–14
Leptospirosis is an infectious disease that causes a fever. It can be severe or fatal. Understanding how many people get leptospirosis helps to determine priorities in allocating resources for disease diagnosis, treatment, and prevention. There are few data about leptospirosis incidence in sub-Sahar...
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| Format: | Online |
| Language: | English |
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Public Library of Science
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135036/ |
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pubmed-5135036 |
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pubmed-51350362016-12-21 Comparison of the Estimated Incidence of Acute Leptospirosis in the Kilimanjaro Region of Tanzania between 2007–08 and 2012–14 Maze, Michael J. Biggs, Holly M. Rubach, Matthew P. Galloway, Renee L. Cash-Goldwasser, Shama Allan, Kathryn J. Halliday, Jo E. B. Hertz, Julian T. Saganda, Wilbrod Lwezaula, Bingileki F. Cleaveland, Sarah Mmbaga, Blandina T. Maro, Venance P. Crump, John A. Research Article Leptospirosis is an infectious disease that causes a fever. It can be severe or fatal. Understanding how many people get leptospirosis helps to determine priorities in allocating resources for disease diagnosis, treatment, and prevention. There are few data about leptospirosis incidence in sub-Saharan African countries. The only mainland estimate is from northern Tanzania for the years 2007–08. To see if leptospirosis incidence had changed since 2007–08, we measured leptospirosis incidence in the same location in 2012–2014. To do this, we systematically approached people at two hospitals in the Kilimanjaro Region and tested them for leptospirosis. We adjusted the number of identified cases of leptospirosis found at the hospitals to account for people with fever who did not come to hospital for testing and care. We also adjusted for imperfect testing methods. We found that the number of people who developed leptospirosis annually had dropped from 75–102 cases per 100,000 people during 2007–08 to 11–18 cases per 100,000 people during 2012–14. Also, the subtype of leptospirosis responsible for the most cases during 2007–08 was not present during 2012–14. The number of people developing leptospirosis was not stable, highlighting the value of measuring how commonly leptospirosis occurs over several years. Public Library of Science 2016-12-02 /pmc/articles/PMC5135036/ /pubmed/27911902 http://dx.doi.org/10.1371/journal.pntd.0005165 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Maze, Michael J. Biggs, Holly M. Rubach, Matthew P. Galloway, Renee L. Cash-Goldwasser, Shama Allan, Kathryn J. Halliday, Jo E. B. Hertz, Julian T. Saganda, Wilbrod Lwezaula, Bingileki F. Cleaveland, Sarah Mmbaga, Blandina T. Maro, Venance P. Crump, John A. |
| spellingShingle |
Maze, Michael J. Biggs, Holly M. Rubach, Matthew P. Galloway, Renee L. Cash-Goldwasser, Shama Allan, Kathryn J. Halliday, Jo E. B. Hertz, Julian T. Saganda, Wilbrod Lwezaula, Bingileki F. Cleaveland, Sarah Mmbaga, Blandina T. Maro, Venance P. Crump, John A. Comparison of the Estimated Incidence of Acute Leptospirosis in the Kilimanjaro Region of Tanzania between 2007–08 and 2012–14 |
| author_facet |
Maze, Michael J. Biggs, Holly M. Rubach, Matthew P. Galloway, Renee L. Cash-Goldwasser, Shama Allan, Kathryn J. Halliday, Jo E. B. Hertz, Julian T. Saganda, Wilbrod Lwezaula, Bingileki F. Cleaveland, Sarah Mmbaga, Blandina T. Maro, Venance P. Crump, John A. |
| author_sort |
Maze, Michael J. |
| title |
Comparison of the Estimated Incidence of Acute Leptospirosis in the Kilimanjaro Region of Tanzania between 2007–08 and 2012–14 |
| title_short |
Comparison of the Estimated Incidence of Acute Leptospirosis in the Kilimanjaro Region of Tanzania between 2007–08 and 2012–14 |
| title_full |
Comparison of the Estimated Incidence of Acute Leptospirosis in the Kilimanjaro Region of Tanzania between 2007–08 and 2012–14 |
| title_fullStr |
Comparison of the Estimated Incidence of Acute Leptospirosis in the Kilimanjaro Region of Tanzania between 2007–08 and 2012–14 |
| title_full_unstemmed |
Comparison of the Estimated Incidence of Acute Leptospirosis in the Kilimanjaro Region of Tanzania between 2007–08 and 2012–14 |
| title_sort |
comparison of the estimated incidence of acute leptospirosis in the kilimanjaro region of tanzania between 2007–08 and 2012–14 |
| description |
Leptospirosis is an infectious disease that causes a fever. It can be severe or fatal. Understanding how many people get leptospirosis helps to determine priorities in allocating resources for disease diagnosis, treatment, and prevention. There are few data about leptospirosis incidence in sub-Saharan African countries. The only mainland estimate is from northern Tanzania for the years 2007–08. To see if leptospirosis incidence had changed since 2007–08, we measured leptospirosis incidence in the same location in 2012–2014. To do this, we systematically approached people at two hospitals in the Kilimanjaro Region and tested them for leptospirosis. We adjusted the number of identified cases of leptospirosis found at the hospitals to account for people with fever who did not come to hospital for testing and care. We also adjusted for imperfect testing methods. We found that the number of people who developed leptospirosis annually had dropped from 75–102 cases per 100,000 people during 2007–08 to 11–18 cases per 100,000 people during 2012–14. Also, the subtype of leptospirosis responsible for the most cases during 2007–08 was not present during 2012–14. The number of people developing leptospirosis was not stable, highlighting the value of measuring how commonly leptospirosis occurs over several years. |
| publisher |
Public Library of Science |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135036/ |
| _version_ |
1613754533953929216 |