Adeno-associated virus-mediated CASQ2 delivery rescues phenotypic alterations in a patient-specific model of recessive catecholaminergic polymorphic ventricular tachycardia

Adeno-associated virus-mediated CASQ2 delivery rescues phenotypic alterations in a patient-specific model of recessive catecholaminergic polymorphic ventricular tachycardia

Catecholaminergic Polymorphic Ventricular Tachycardia type 2 (CPVT2) is a highly lethal recessive arrhythmogenic disease caused by mutations in the calsequestrin-2 (CASQ2) gene. We have previously demonstrated that viral transfer of the wild-type (WT) CASQ2 gene prevents the development of CPVT2 in...

Full description

Bibliographic Details
Main Authors: Lodola, Francesco, Morone, Diego, Denegri, Marco, Bongianino, Rossana, Nakahama, Hiroko, Rutigliano, Lucia, Gosetti, Rosanna, Rizzo, Giulia, Vollero, Alessandra, Buonocore, Michelangelo, Napolitano, Carlo, Condorelli, Gianluigi, Priori, Silvia G, Di Pasquale, Elisa
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133973/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133973/

Similar Items