Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB

Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB

Sirtuin 1 (Sirt1) is a deacetylase that regulates many cellular processes in the liver, and so far its role in endotoxemic liver injury is elusive. So we conditionally inactivate Sirt1 in murine hepatocytes to determine its role in d-galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver damage...

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Bibliographic Details
Main Authors: Cui, Xiaolan, Chen, Qian, Dong, Zhen, Xu, Longmei, Lu, Tianfei, Li, Dawei, Zhang, Jiangjun, Zhang, Ming, Xia, Qiang
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133964/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133964/

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