Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan

Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan

Human embryonic stem cells can replicate indefinitely while maintaining their undifferentiated state and, therefore, are immortal in culture. This capacity may demand avoidance of any imbalance in protein homeostasis (proteostasis) that would otherwise compromise stem cell identity. Here we show tha...

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Bibliographic Details
Main Authors: Noormohammadi, Alireza, Khodakarami, Amirabbas, Gutierrez-Garcia, Ricardo, Lee, Hyun Ju, Koyuncu, Seda, König, Tim, Schindler, Christina, Saez, Isabel, Fatima, Azra, Dieterich, Christoph, Vilchez, David
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133698/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133698/

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