ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites

ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites

•Synthesis of 46 BVdU ProTide derivatives with superior activity over BVdU.•Anti-proliferative activity against L1210, CEM, HeLa and HEL cell lines.•Up to 20-fold cytostatic activity enhancement over the parent BVdU.•Retention or increase of the cytostatic activity against TK-deficient cancer cells....

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Bibliographic Details
Main Authors: Kandil, Sahar, Balzarini, Jan, Rat, Stephanie, Brancale, Andrea, Westwell, Andrew D., McGuigan, Christopher
Format: Online
Language:English
Published: Elsevier Science Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131913/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131913/

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