Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice

The immune correlate of host resistance induced by reinfection of Trichinella spiralis remains unclear. In this study, we investigated immune correlates between the resistance and serum IgG antibody level, CD23+ IgM+ B cells, and eosinophil responses induced by T. spiralis reinfection. Mice were pri...

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Main Authors:	Chu, Ki-Back, Kim, Sang-Soo, Lee, Su-Hwa, Lee, Dong-Hun, Kim, Ah-Ra, Quan, Fu-Shi
Format:	Online
Language:	English
Published:	The Korean Society for Parasitology and Tropical Medicine 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127533/

id	pubmed-5127533
recordtype	oai_dc
spelling	pubmed-51275332016-11-30 Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice Chu, Ki-Back Kim, Sang-Soo Lee, Su-Hwa Lee, Dong-Hun Kim, Ah-Ra Quan, Fu-Shi Original Article The immune correlate of host resistance induced by reinfection of Trichinella spiralis remains unclear. In this study, we investigated immune correlates between the resistance and serum IgG antibody level, CD23+ IgM+ B cells, and eosinophil responses induced by T. spiralis reinfection. Mice were primarily infected with 10 or 100 T. spiralis larvae (10 TS, 100 TS), respectively, and after 4 weeks, they were challenge infected with 100 T. spiralis larvae (10–100 TS, 100-100 TS). Upon challenge infections, 10–100 TS mice induced significantly higher levels of T. spiralis-specific total IgG antibody responses in sera and antibody secreting cell responses in spleens compared to 100-100 TS mice, resulting in significantly reduced worm burdens in 10–100 TS mice (60% and 70% reductions for adult and larvae, respectively). Higher levels of eosinophils were found in mice primarily infected with 10 TS compared to those of 100 TS at week 8 upon challenge. CD23+ IgM+ B cells were found to be increased significantly in mice primarily infected with 10 TS. These results indicate that primary infection of 10 larvae of T. spiralis, rather than 100 larvae, induces significant resistance against reinfection which closely correlated with T. spiralis-specific IgG, eosinophil, and CD23+ IgM+ B cell responses. The Korean Society for Parasitology and Tropical Medicine 2016-10 2016-10-31 /pmc/articles/PMC5127533/ /pubmed/27853121 http://dx.doi.org/10.3347/kjp.2016.54.5.637 Text en Copyright © 2016 by The Korean Society for Parasitology and Tropical Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chu, Ki-Back Kim, Sang-Soo Lee, Su-Hwa Lee, Dong-Hun Kim, Ah-Ra Quan, Fu-Shi
spellingShingle	Chu, Ki-Back Kim, Sang-Soo Lee, Su-Hwa Lee, Dong-Hun Kim, Ah-Ra Quan, Fu-Shi Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
author_facet	Chu, Ki-Back Kim, Sang-Soo Lee, Su-Hwa Lee, Dong-Hun Kim, Ah-Ra Quan, Fu-Shi
author_sort	Chu, Ki-Back
title	Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
title_short	Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
title_full	Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
title_fullStr	Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
title_full_unstemmed	Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
title_sort	immune correlates of resistance to trichinella spiralis reinfection in mice
description	The immune correlate of host resistance induced by reinfection of Trichinella spiralis remains unclear. In this study, we investigated immune correlates between the resistance and serum IgG antibody level, CD23+ IgM+ B cells, and eosinophil responses induced by T. spiralis reinfection. Mice were primarily infected with 10 or 100 T. spiralis larvae (10 TS, 100 TS), respectively, and after 4 weeks, they were challenge infected with 100 T. spiralis larvae (10–100 TS, 100-100 TS). Upon challenge infections, 10–100 TS mice induced significantly higher levels of T. spiralis-specific total IgG antibody responses in sera and antibody secreting cell responses in spleens compared to 100-100 TS mice, resulting in significantly reduced worm burdens in 10–100 TS mice (60% and 70% reductions for adult and larvae, respectively). Higher levels of eosinophils were found in mice primarily infected with 10 TS compared to those of 100 TS at week 8 upon challenge. CD23+ IgM+ B cells were found to be increased significantly in mice primarily infected with 10 TS. These results indicate that primary infection of 10 larvae of T. spiralis, rather than 100 larvae, induces significant resistance against reinfection which closely correlated with T. spiralis-specific IgG, eosinophil, and CD23+ IgM+ B cell responses.
publisher	The Korean Society for Parasitology and Tropical Medicine
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127533/
_version_	1613745338712064000

Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice

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