Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion

Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion

The cystic fibrosis (CF) airway surface liquid (ASL) provides a nutrient rich environment for bacterial growth including elevated glucose, which together with defective bacterial killing due to aberrant HCO3− transport and acidic ASL, make the CF airways susceptible to colonisation by respiratory pa...

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Bibliographic Details
Main Authors: Garnett, James Peter, Kalsi, Kameljit K., Sobotta, Mirko, Bearham, Jade, Carr, Georgina, Powell, Jason, Brodlie, Malcolm, Ward, Christopher, Tarran, Robert, Baines, Deborah L.
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126573/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126573/

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