NADPH oxidase gp91phox contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1

Bone-marrow derived monocyte-macrophages (BMMs) differentiate into osteoclasts by M-CSF along subsequent RANKL stimulation possibly in collaboration with many other unknown cytokines released by pre- or mature osteoblasts. The differentiation process requires receptor activator of nuclear factor kap...

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Bibliographic Details
Main Authors: Kang, In Soon, Kim, Chaekyun
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126560/