Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification

Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification

Knowledge of influenza virus evolution at the point of transmission and at the intrahost level remains limited, particularly for human hosts. Here, we analyze a unique viral data set of next-generation sequencing (NGS) samples generated from a human influenza challenge study wherein 17 healthy subje...

Full description

Bibliographic Details
Main Authors: Sobel Leonard, Ashley, McClain, Micah T., Smith, Gavin J. D., Wentworth, David E., Halpin, Rebecca A., Lin, Xudong, Ransier, Amy, Stockwell, Timothy B., Das, Suman R., Gilbert, Anthony S., Lambkin-Williams, Robert, Ginsburg, Geoffrey S., Woods, Christopher W., Koelle, Katia
Format: Online
Language:English
Published: American Society for Microbiology 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126380/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126380/

Similar Items