In vivo measurement of hemodynamic information in stenosed rat blood vessels using X-ray PIV
Measurements of the hemodynamic information of blood flows, especially wall shear stress (WSS), in animal models with circulatory vascular diseases (CVDs) are important to understand the pathological mechanism of CVDs. In this study, X-ray particle image velocimetry (PIV) with high spatial resolutio...
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| Format: | Online |
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Nature Publishing Group
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125094/ |
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pubmed-51250942016-12-08 In vivo measurement of hemodynamic information in stenosed rat blood vessels using X-ray PIV Park, Hanwook Park, Jun Hong Lee, Sang Joon Article Measurements of the hemodynamic information of blood flows, especially wall shear stress (WSS), in animal models with circulatory vascular diseases (CVDs) are important to understand the pathological mechanism of CVDs. In this study, X-ray particle image velocimetry (PIV) with high spatial resolution was applied to obtain velocity field information in stenosed blood vessels with high WSS. 3D clips fabricated with a 3D printer were applied to the abdominal aorta of a rat cadaver to induce artificial stenosis in the real blood vessel of an animal model. The velocity and WSS information of blood flows in the stenosed vessel were obtained and compared at various stenosis severities. In vivo measurement was also conducted by fastening a stenotic clip on a live rat model through surgical intervention to reduce the flow rate to match the limited temporal resolution of the present X-ray PIV system. Further improvement of the temporal resolution of the system might be able to provide in vivo measurements of hemodynamic information from animal disease models under physiological conditions. The present results would be helpful for understanding the relation between hemodynamic characteristics and the pathological mechanism in animal CVD models. Nature Publishing Group 2016-11-28 /pmc/articles/PMC5125094/ /pubmed/27892505 http://dx.doi.org/10.1038/srep37985 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Park, Hanwook Park, Jun Hong Lee, Sang Joon |
| spellingShingle |
Park, Hanwook Park, Jun Hong Lee, Sang Joon In vivo measurement of hemodynamic information in stenosed rat blood vessels using X-ray PIV |
| author_facet |
Park, Hanwook Park, Jun Hong Lee, Sang Joon |
| author_sort |
Park, Hanwook |
| title |
In vivo measurement of hemodynamic information in stenosed rat blood vessels using X-ray PIV |
| title_short |
In vivo measurement of hemodynamic information in stenosed rat blood vessels using X-ray PIV |
| title_full |
In vivo measurement of hemodynamic information in stenosed rat blood vessels using X-ray PIV |
| title_fullStr |
In vivo measurement of hemodynamic information in stenosed rat blood vessels using X-ray PIV |
| title_full_unstemmed |
In vivo measurement of hemodynamic information in stenosed rat blood vessels using X-ray PIV |
| title_sort |
in vivo measurement of hemodynamic information in stenosed rat blood vessels using x-ray piv |
| description |
Measurements of the hemodynamic information of blood flows, especially wall shear stress (WSS), in animal models with circulatory vascular diseases (CVDs) are important to understand the pathological mechanism of CVDs. In this study, X-ray particle image velocimetry (PIV) with high spatial resolution was applied to obtain velocity field information in stenosed blood vessels with high WSS. 3D clips fabricated with a 3D printer were applied to the abdominal aorta of a rat cadaver to induce artificial stenosis in the real blood vessel of an animal model. The velocity and WSS information of blood flows in the stenosed vessel were obtained and compared at various stenosis severities. In vivo measurement was also conducted by fastening a stenotic clip on a live rat model through surgical intervention to reduce the flow rate to match the limited temporal resolution of the present X-ray PIV system. Further improvement of the temporal resolution of the system might be able to provide in vivo measurements of hemodynamic information from animal disease models under physiological conditions. The present results would be helpful for understanding the relation between hemodynamic characteristics and the pathological mechanism in animal CVD models. |
| publisher |
Nature Publishing Group |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125094/ |
| _version_ |
1613742953391456256 |