Genetics and pathogenesis of idiopathic scoliosis
Idiopathic scoliosis (IS), the most common spinal deformity, affects otherwise healthy children and adolescents during growth. The aetiology is still unknown, although genetic factors are believed to be important. The present review corroborates the understanding of IS as a complex disease with a po...
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| Format: | Online |
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BioMed Central
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125035/ |
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pubmed-51250352016-12-08 Genetics and pathogenesis of idiopathic scoliosis Grauers, A. Einarsdottir, E. Gerdhem, P. Review Idiopathic scoliosis (IS), the most common spinal deformity, affects otherwise healthy children and adolescents during growth. The aetiology is still unknown, although genetic factors are believed to be important. The present review corroborates the understanding of IS as a complex disease with a polygenic background. Presumably IS can be due to a spectrum of genetic risk variants, ranging from very rare or even private to very common. The most promising candidate genes are highlighted. BioMed Central 2016-11-28 /pmc/articles/PMC5125035/ /pubmed/27933320 http://dx.doi.org/10.1186/s13013-016-0105-8 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Grauers, A. Einarsdottir, E. Gerdhem, P. |
| spellingShingle |
Grauers, A. Einarsdottir, E. Gerdhem, P. Genetics and pathogenesis of idiopathic scoliosis |
| author_facet |
Grauers, A. Einarsdottir, E. Gerdhem, P. |
| author_sort |
Grauers, A. |
| title |
Genetics and pathogenesis of idiopathic scoliosis |
| title_short |
Genetics and pathogenesis of idiopathic scoliosis |
| title_full |
Genetics and pathogenesis of idiopathic scoliosis |
| title_fullStr |
Genetics and pathogenesis of idiopathic scoliosis |
| title_full_unstemmed |
Genetics and pathogenesis of idiopathic scoliosis |
| title_sort |
genetics and pathogenesis of idiopathic scoliosis |
| description |
Idiopathic scoliosis (IS), the most common spinal deformity, affects otherwise healthy children and adolescents during growth. The aetiology is still unknown, although genetic factors are believed to be important. The present review corroborates the understanding of IS as a complex disease with a polygenic background. Presumably IS can be due to a spectrum of genetic risk variants, ranging from very rare or even private to very common. The most promising candidate genes are highlighted. |
| publisher |
BioMed Central |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125035/ |
| _version_ |
1613742896884744192 |