Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases

Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases

Mevalonate kinase deficiency (MKD) is caused by mutations in a key enzyme of the mevalonate–cholesterol biosynthesis pathway, leading to recurrent autoinflammatory disease characterised by enhanced release of interleukin-1β (IL-1β). It is currently believed that the inflammatory phenotype of MKD is...

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Bibliographic Details
Main Authors: Jurczyluk, Julie, Munoz, Marcia A, Skinner, Oliver P, Chai, Ryan C, Ali, Naveid, Palendira, Umaimainthan, Quinn, Julian MW, Preston, Alexandra, Tangye, Stuart G, Brown, Andrew J, Argent, Elizabeth, Ziegler, John B, Mehr, Sam, Rogers, Michael J
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122740/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122740/

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