Enhanced anti-tumor activity and cytotoxic effect on cancer stem cell population of metformin-butyrate compared with metformin HCl in breast cancer

Enhanced anti-tumor activity and cytotoxic effect on cancer stem cell population of metformin-butyrate compared with metformin HCl in breast cancer

Metformin, which is a drug commonly used to treat type 2 diabetes, has shown anti-tumor effects in numerous experimental, epidemiologic, observational, and clinical studies. Here, we report a new metformin derivative, metformin-butyrate (MFB). Compared to metformin-HCl, it more potently activates AM...

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Bibliographic Details
Main Authors: Lee, Kyung-Min, Lee, Minju, Lee, Jiwoo, Kim, Sung Wuk, Moon, Hyeong-Gon, Noh, Dong-Young, Han, Wonshik
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122406/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122406/

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