Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity

Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity

Impaired glucose homeostasis and energy balance are integral to the pathophysiology of diabetes and obesity. Here we show that administration of a glycine transporter 1 (GlyT1) inhibitor, or molecular GlyT1 knockdown, in the dorsal vagal complex (DVC) suppresses glucose production, increases glucose...

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Bibliographic Details
Main Authors: Yue, Jessica T. Y., Abraham, Mona A., Bauer, Paige V., LaPierre, Mary P., Wang, Peili, Duca, Frank A., Filippi, Beatrice M., Chan, Owen, Lam, Tony K. T.
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121412/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121412/

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