Phylogeography of Crimean Congo Hemorrhagic Fever Virus

Crimean Congo hemorrhagic fever virus (CCHFV) is one of the most severe viral zoonozes. It is prevalent throughout Africa, Asia and southern Europe. Limited availability of sequence data has hindered phylogeographic studies. The complete genomic sequence of all three segments of 14 Crimean Congo hem...

Full description

Bibliographic Details
Main Authors:	Lukashev, Alexander N., Klimentov, Alexander S., Smirnova, Svetlana E., Dzagurova, Tamara K., Drexler, Jan Felix, Gmyl, Anatoly P.
Format:	Online
Language:	English
Published:	Public Library of Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120814/

id	pubmed-5120814
recordtype	oai_dc
spelling	pubmed-51208142016-12-15 Phylogeography of Crimean Congo Hemorrhagic Fever Virus Lukashev, Alexander N. Klimentov, Alexander S. Smirnova, Svetlana E. Dzagurova, Tamara K. Drexler, Jan Felix Gmyl, Anatoly P. Research Article Crimean Congo hemorrhagic fever virus (CCHFV) is one of the most severe viral zoonozes. It is prevalent throughout Africa, Asia and southern Europe. Limited availability of sequence data has hindered phylogeographic studies. The complete genomic sequence of all three segments of 14 Crimean Congo hemorrhagic fever virus strains isolated from 1958–2000 in Russia, Central Asia and Africa was identified. Each genomic segment was independently subjected to continuous Bayesian phylogeographic analysis. The origin of each genomic segment was traced to Africa about 1,000–5,000 years ago. The virus was first introduced to South and Central Asia in the Middle Ages, and then spread to China, India and Russia. Reverse transfers of genomic segments from Asia to Africa were also observed. The European CCHFV genotype V was introduced to Europe via the Astrakhan region in South Russia 280–400 years ago and subsequently gradually spread westward in Russia, to Turkey and the Balkans less than 150 years ago. Only a few recombination events could be suggested in S and L genomic segments, while segment reassortment was very common. The median height of a non-reassortant phylogenetic tree node was 68–156 years. There were reassortment events within the European CCHFV lineage, but not with viruses from other locations. Therefore, CCHFV in Europe is a recently emerged zoonosis that represents a spillover from the global gene pool. Public Library of Science 2016-11-23 /pmc/articles/PMC5120814/ /pubmed/27880794 http://dx.doi.org/10.1371/journal.pone.0166744 Text en © 2016 Lukashev et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lukashev, Alexander N. Klimentov, Alexander S. Smirnova, Svetlana E. Dzagurova, Tamara K. Drexler, Jan Felix Gmyl, Anatoly P.
spellingShingle	Lukashev, Alexander N. Klimentov, Alexander S. Smirnova, Svetlana E. Dzagurova, Tamara K. Drexler, Jan Felix Gmyl, Anatoly P. Phylogeography of Crimean Congo Hemorrhagic Fever Virus
author_facet	Lukashev, Alexander N. Klimentov, Alexander S. Smirnova, Svetlana E. Dzagurova, Tamara K. Drexler, Jan Felix Gmyl, Anatoly P.
author_sort	Lukashev, Alexander N.
title	Phylogeography of Crimean Congo Hemorrhagic Fever Virus
title_short	Phylogeography of Crimean Congo Hemorrhagic Fever Virus
title_full	Phylogeography of Crimean Congo Hemorrhagic Fever Virus
title_fullStr	Phylogeography of Crimean Congo Hemorrhagic Fever Virus
title_full_unstemmed	Phylogeography of Crimean Congo Hemorrhagic Fever Virus
title_sort	phylogeography of crimean congo hemorrhagic fever virus
description	Crimean Congo hemorrhagic fever virus (CCHFV) is one of the most severe viral zoonozes. It is prevalent throughout Africa, Asia and southern Europe. Limited availability of sequence data has hindered phylogeographic studies. The complete genomic sequence of all three segments of 14 Crimean Congo hemorrhagic fever virus strains isolated from 1958–2000 in Russia, Central Asia and Africa was identified. Each genomic segment was independently subjected to continuous Bayesian phylogeographic analysis. The origin of each genomic segment was traced to Africa about 1,000–5,000 years ago. The virus was first introduced to South and Central Asia in the Middle Ages, and then spread to China, India and Russia. Reverse transfers of genomic segments from Asia to Africa were also observed. The European CCHFV genotype V was introduced to Europe via the Astrakhan region in South Russia 280–400 years ago and subsequently gradually spread westward in Russia, to Turkey and the Balkans less than 150 years ago. Only a few recombination events could be suggested in S and L genomic segments, while segment reassortment was very common. The median height of a non-reassortant phylogenetic tree node was 68–156 years. There were reassortment events within the European CCHFV lineage, but not with viruses from other locations. Therefore, CCHFV in Europe is a recently emerged zoonosis that represents a spillover from the global gene pool.
publisher	Public Library of Science
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120814/
_version_	1613738573184368640

Phylogeography of Crimean Congo Hemorrhagic Fever Virus

Similar Items