Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma

Long noncoding RNAs (lncRNAs) play crucial roles in cancer occurrence and progression. However, the relationship between the expression levels of lncRNAs and the hepatocellular carcinoma (HCC) process is unclear. The goal of this study was to determine the expression level of ZNF674-AS1, a newly fou...

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Main Authors:	Zhang, Lufei, He, Tianyu, Yan, Yingcai, Zhang, Yuan, Zhou, Xiaohu, Huang, Pengfei, Kong, Yang, Xie, Minjie, Zhang, Linshi, Sun, Qiang, Zhou, Dongkai, Xie, Haiyang, Zhou, Lin, Zheng, Shusen, Wang, Weilin
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118518/

id	pubmed-5118518
recordtype	oai_dc
spelling	pubmed-51185182016-11-28 Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma Zhang, Lufei He, Tianyu Yan, Yingcai Zhang, Yuan Zhou, Xiaohu Huang, Pengfei Kong, Yang Xie, Minjie Zhang, Linshi Sun, Qiang Zhou, Dongkai Xie, Haiyang Zhou, Lin Zheng, Shusen Wang, Weilin Research Article Long noncoding RNAs (lncRNAs) play crucial roles in cancer occurrence and progression. However, the relationship between the expression levels of lncRNAs and the hepatocellular carcinoma (HCC) process is unclear. The goal of this study was to determine the expression level of ZNF674-AS1, a newly found lncRNA, in HCC and its clinical association. The expression of ZNF674-AS1 in 137 pairs of tumorous and adjacent normal tissues from patients with HCC was detected by quantitative real-time reverse transcription polymerase chain reaction. Additionally, the potential associations between its level in HCC tissue and clinicopathological features were analyzed. The expression of ZNF674-AS1 in the HCC cell lines HepG2, HCCLM3, SK-Hep1, HuH7, Hep3B, and MHCC97H was significantly downregulated compared with that in the normal liver cell line QSG-7701. The expression of ZNF674-AS1 was downregulated in 72% (99/137) of HCC tissues compared with that in paired adjacent normal tissues (p < 0.01). The results showed that the ZNF674-AS1 expression level was significantly correlated with metastasis (p = 0.041), clinical stage (p = 0.039), and histopathologic grading (p = 0.045). In addition, the Kaplan–Meier survival curves revealed that low ZNF674-AS1 expression was associated with poor prognosis in patients with HCC. Our data suggest that ZNF674-AS1 may play some role during cancer occurrence and progression and may be a new biomarker for HCC. Hindawi Publishing Corporation 2016 2016-11-08 /pmc/articles/PMC5118518/ /pubmed/27896271 http://dx.doi.org/10.1155/2016/3608914 Text en Copyright © 2016 Lufei Zhang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhang, Lufei He, Tianyu Yan, Yingcai Zhang, Yuan Zhou, Xiaohu Huang, Pengfei Kong, Yang Xie, Minjie Zhang, Linshi Sun, Qiang Zhou, Dongkai Xie, Haiyang Zhou, Lin Zheng, Shusen Wang, Weilin
spellingShingle	Zhang, Lufei He, Tianyu Yan, Yingcai Zhang, Yuan Zhou, Xiaohu Huang, Pengfei Kong, Yang Xie, Minjie Zhang, Linshi Sun, Qiang Zhou, Dongkai Xie, Haiyang Zhou, Lin Zheng, Shusen Wang, Weilin Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma
author_facet	Zhang, Lufei He, Tianyu Yan, Yingcai Zhang, Yuan Zhou, Xiaohu Huang, Pengfei Kong, Yang Xie, Minjie Zhang, Linshi Sun, Qiang Zhou, Dongkai Xie, Haiyang Zhou, Lin Zheng, Shusen Wang, Weilin
author_sort	Zhang, Lufei
title	Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma
title_short	Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma
title_full	Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma
title_fullStr	Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma
title_full_unstemmed	Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma
title_sort	expression and clinical significance of the novel long noncoding rna znf674-as1 in human hepatocellular carcinoma
description	Long noncoding RNAs (lncRNAs) play crucial roles in cancer occurrence and progression. However, the relationship between the expression levels of lncRNAs and the hepatocellular carcinoma (HCC) process is unclear. The goal of this study was to determine the expression level of ZNF674-AS1, a newly found lncRNA, in HCC and its clinical association. The expression of ZNF674-AS1 in 137 pairs of tumorous and adjacent normal tissues from patients with HCC was detected by quantitative real-time reverse transcription polymerase chain reaction. Additionally, the potential associations between its level in HCC tissue and clinicopathological features were analyzed. The expression of ZNF674-AS1 in the HCC cell lines HepG2, HCCLM3, SK-Hep1, HuH7, Hep3B, and MHCC97H was significantly downregulated compared with that in the normal liver cell line QSG-7701. The expression of ZNF674-AS1 was downregulated in 72% (99/137) of HCC tissues compared with that in paired adjacent normal tissues (p < 0.01). The results showed that the ZNF674-AS1 expression level was significantly correlated with metastasis (p = 0.041), clinical stage (p = 0.039), and histopathologic grading (p = 0.045). In addition, the Kaplan–Meier survival curves revealed that low ZNF674-AS1 expression was associated with poor prognosis in patients with HCC. Our data suggest that ZNF674-AS1 may play some role during cancer occurrence and progression and may be a new biomarker for HCC.
publisher	Hindawi Publishing Corporation
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118518/
_version_	1613736099234971648

Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma

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