Respiratory viral infections and host responses; insights from genomics
Respiratory viral infections are a leading cause of disease and mortality. The severity of these illnesses can vary markedly from mild or asymptomatic upper airway infections to severe wheezing, bronchiolitis or pneumonia. In this article, we review the viral sensing pathways and organizing principl...
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| Format: | Online |
| Language: | English |
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BioMed Central
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117516/ |
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pubmed-51175162016-11-28 Respiratory viral infections and host responses; insights from genomics Troy, Niamh M. Bosco, Anthony Review Respiratory viral infections are a leading cause of disease and mortality. The severity of these illnesses can vary markedly from mild or asymptomatic upper airway infections to severe wheezing, bronchiolitis or pneumonia. In this article, we review the viral sensing pathways and organizing principles that govern the innate immune response to infection. Then, we reconstruct the molecular networks that differentiate symptomatic from asymptomatic respiratory viral infections, and identify the underlying molecular drivers of these networks. Finally, we discuss unique aspects of the biology and pathogenesis of infections with respiratory syncytial virus, rhinovirus and influenza, drawing on insights from genomics. BioMed Central 2016-11-21 2016 /pmc/articles/PMC5117516/ /pubmed/27871304 http://dx.doi.org/10.1186/s12931-016-0474-9 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Troy, Niamh M. Bosco, Anthony |
| spellingShingle |
Troy, Niamh M. Bosco, Anthony Respiratory viral infections and host responses; insights from genomics |
| author_facet |
Troy, Niamh M. Bosco, Anthony |
| author_sort |
Troy, Niamh M. |
| title |
Respiratory viral infections and host responses; insights from genomics |
| title_short |
Respiratory viral infections and host responses; insights from genomics |
| title_full |
Respiratory viral infections and host responses; insights from genomics |
| title_fullStr |
Respiratory viral infections and host responses; insights from genomics |
| title_full_unstemmed |
Respiratory viral infections and host responses; insights from genomics |
| title_sort |
respiratory viral infections and host responses; insights from genomics |
| description |
Respiratory viral infections are a leading cause of disease and mortality. The severity of these illnesses can vary markedly from mild or asymptomatic upper airway infections to severe wheezing, bronchiolitis or pneumonia. In this article, we review the viral sensing pathways and organizing principles that govern the innate immune response to infection. Then, we reconstruct the molecular networks that differentiate symptomatic from asymptomatic respiratory viral infections, and identify the underlying molecular drivers of these networks. Finally, we discuss unique aspects of the biology and pathogenesis of infections with respiratory syncytial virus, rhinovirus and influenza, drawing on insights from genomics. |
| publisher |
BioMed Central |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117516/ |
| _version_ |
1613735245629095936 |