Main Effects of Diagnoses, Brain Regions, and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders

Previous studies suggested patients with bipolar depressive disorder (BDd) or unipolar depressive disorder (UDd) have cerebral metabolites abnormalities. These abnormalities may stem from multiple sub-regions of gray matter in brain regions. Thirteen BDd patients, 20 UDd patients and 20 healthy cont...

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Main Authors:	Tan, Hai-Zhu, Li, Hui, Liu, Chen-Feng, Guan, Ji-Tian, Guo, Xiao-Bo, Wen, Can-Hong, Ou, Shao-Min, Zhang, Yin-Nan, Zhang, Jie, Xu, Chong-Tao, Shen, Zhi-Wei, Wu, Ren-Hua, Wang, Xue-Qin
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116758/

id	pubmed-5116758
recordtype	oai_dc
spelling	pubmed-51167582016-11-28 Main Effects of Diagnoses, Brain Regions, and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders Tan, Hai-Zhu Li, Hui Liu, Chen-Feng Guan, Ji-Tian Guo, Xiao-Bo Wen, Can-Hong Ou, Shao-Min Zhang, Yin-Nan Zhang, Jie Xu, Chong-Tao Shen, Zhi-Wei Wu, Ren-Hua Wang, Xue-Qin Article Previous studies suggested patients with bipolar depressive disorder (BDd) or unipolar depressive disorder (UDd) have cerebral metabolites abnormalities. These abnormalities may stem from multiple sub-regions of gray matter in brain regions. Thirteen BDd patients, 20 UDd patients and 20 healthy controls (HC) were enrolled to investigate these abnormalities. Absolute concentrations of 5 cerebral metabolites (glutamate-glutamine (Glx), N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), creatine (Cr), parietal cortex (PC)) were measured from 4 subregions (the medial frontal cortex (mPFC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and parietal cortex (PC)) of gray matter. Main and interaction effects of cerebral metabolites across subregions of gray matter were evaluated. For example, the Glx was significantly higher in BDd compared with UDd, and so on. As the interaction analyses showed, some interaction effects existed. The concentrations of BDds’ Glx, Cho, Cr in the ACC and HCs’ mI and Cr in the PC were higher than that of other interaction effects. In addition, the concentrations of BDds’ Glx and Cr in the PC and HCs’ mI in the ACC were statistically significant lower than that of other interaction effects. These findings point to region-related abnormalities of cerebral metabolites across subjects with BDd and UDd. Nature Publishing Group 2016-11-21 /pmc/articles/PMC5116758/ /pubmed/27869127 http://dx.doi.org/10.1038/srep37343 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tan, Hai-Zhu Li, Hui Liu, Chen-Feng Guan, Ji-Tian Guo, Xiao-Bo Wen, Can-Hong Ou, Shao-Min Zhang, Yin-Nan Zhang, Jie Xu, Chong-Tao Shen, Zhi-Wei Wu, Ren-Hua Wang, Xue-Qin
spellingShingle	Tan, Hai-Zhu Li, Hui Liu, Chen-Feng Guan, Ji-Tian Guo, Xiao-Bo Wen, Can-Hong Ou, Shao-Min Zhang, Yin-Nan Zhang, Jie Xu, Chong-Tao Shen, Zhi-Wei Wu, Ren-Hua Wang, Xue-Qin Main Effects of Diagnoses, Brain Regions, and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders
author_facet	Tan, Hai-Zhu Li, Hui Liu, Chen-Feng Guan, Ji-Tian Guo, Xiao-Bo Wen, Can-Hong Ou, Shao-Min Zhang, Yin-Nan Zhang, Jie Xu, Chong-Tao Shen, Zhi-Wei Wu, Ren-Hua Wang, Xue-Qin
author_sort	Tan, Hai-Zhu
title	Main Effects of Diagnoses, Brain Regions, and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders
title_short	Main Effects of Diagnoses, Brain Regions, and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders
title_full	Main Effects of Diagnoses, Brain Regions, and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders
title_fullStr	Main Effects of Diagnoses, Brain Regions, and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders
title_full_unstemmed	Main Effects of Diagnoses, Brain Regions, and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders
title_sort	main effects of diagnoses, brain regions, and their interaction effects for cerebral metabolites in bipolar and unipolar depressive disorders
description	Previous studies suggested patients with bipolar depressive disorder (BDd) or unipolar depressive disorder (UDd) have cerebral metabolites abnormalities. These abnormalities may stem from multiple sub-regions of gray matter in brain regions. Thirteen BDd patients, 20 UDd patients and 20 healthy controls (HC) were enrolled to investigate these abnormalities. Absolute concentrations of 5 cerebral metabolites (glutamate-glutamine (Glx), N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), creatine (Cr), parietal cortex (PC)) were measured from 4 subregions (the medial frontal cortex (mPFC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and parietal cortex (PC)) of gray matter. Main and interaction effects of cerebral metabolites across subregions of gray matter were evaluated. For example, the Glx was significantly higher in BDd compared with UDd, and so on. As the interaction analyses showed, some interaction effects existed. The concentrations of BDds’ Glx, Cho, Cr in the ACC and HCs’ mI and Cr in the PC were higher than that of other interaction effects. In addition, the concentrations of BDds’ Glx and Cr in the PC and HCs’ mI in the ACC were statistically significant lower than that of other interaction effects. These findings point to region-related abnormalities of cerebral metabolites across subjects with BDd and UDd.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116758/
_version_	1613734540290818048

Main Effects of Diagnoses, Brain Regions, and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders

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