Irradiance-dependent UVB Photocarcinogenesis

Ultraviolet B (UVB) radiation from the sun may lead to photocarcinogenesis of the skin. Sunscreens were used to protect the skin by reducing UVB irradiance, but sunscreen use did not reduce sunburn episodes. It was shown that UVB-induced erythema depends on surface exposure but not irradiance of UVB...

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Main Authors:	Lan, Cheng-Che E., Wu, Ching-Shuang, Huang, Shu-Mei, Wu, Chin-Han, Lai, Hsiao-Chi, Peng, Yu-Ting, Hou, Pao-Sheng, Yang, Hui-Jun, Chen, Gwo-Shing
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116611/

id	pubmed-5116611
recordtype	oai_dc
spelling	pubmed-51166112016-11-28 Irradiance-dependent UVB Photocarcinogenesis Lan, Cheng-Che E. Wu, Ching-Shuang Huang, Shu-Mei Wu, Chin-Han Lai, Hsiao-Chi Peng, Yu-Ting Hou, Pao-Sheng Yang, Hui-Jun Chen, Gwo-Shing Article Ultraviolet B (UVB) radiation from the sun may lead to photocarcinogenesis of the skin. Sunscreens were used to protect the skin by reducing UVB irradiance, but sunscreen use did not reduce sunburn episodes. It was shown that UVB-induced erythema depends on surface exposure but not irradiance of UVB. We previously showed that irradiance plays a critical role in UVB-induced cell differentiation. This study investigated the impact of irradiance on UVB-induced photocarcinogenesis. For hairless mice receiving equivalent exposure of UVB radiation, the low irradiance (LI) UVB treated mice showed more rapid tumor development, larger tumor burden, and more keratinocytes harboring mutant p53 in the epidermis as compared to their high irradiance (HI) UVB treated counterpart. Mechanistically, using cell models, we demonstrated that LI UVB radiation allowed more keratinocytes harboring DNA damages to enter cell cycle via ERK-related signaling as compared to its HI UVB counterpart. These results indicated that at equivalent exposure, UVB radiation at LI has higher photocarcinogenic potential as compared to its HI counterpart. Since erythema is the observed sunburn at moderate doses and use of sunscreen was not found to associate with reduced sunburn episodes, the biological significance of sunburn with or without sunscreen use warrants further investigation. Nature Publishing Group 2016-11-21 /pmc/articles/PMC5116611/ /pubmed/27869214 http://dx.doi.org/10.1038/srep37403 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lan, Cheng-Che E. Wu, Ching-Shuang Huang, Shu-Mei Wu, Chin-Han Lai, Hsiao-Chi Peng, Yu-Ting Hou, Pao-Sheng Yang, Hui-Jun Chen, Gwo-Shing
spellingShingle	Lan, Cheng-Che E. Wu, Ching-Shuang Huang, Shu-Mei Wu, Chin-Han Lai, Hsiao-Chi Peng, Yu-Ting Hou, Pao-Sheng Yang, Hui-Jun Chen, Gwo-Shing Irradiance-dependent UVB Photocarcinogenesis
author_facet	Lan, Cheng-Che E. Wu, Ching-Shuang Huang, Shu-Mei Wu, Chin-Han Lai, Hsiao-Chi Peng, Yu-Ting Hou, Pao-Sheng Yang, Hui-Jun Chen, Gwo-Shing
author_sort	Lan, Cheng-Che E.
title	Irradiance-dependent UVB Photocarcinogenesis
title_short	Irradiance-dependent UVB Photocarcinogenesis
title_full	Irradiance-dependent UVB Photocarcinogenesis
title_fullStr	Irradiance-dependent UVB Photocarcinogenesis
title_full_unstemmed	Irradiance-dependent UVB Photocarcinogenesis
title_sort	irradiance-dependent uvb photocarcinogenesis
description	Ultraviolet B (UVB) radiation from the sun may lead to photocarcinogenesis of the skin. Sunscreens were used to protect the skin by reducing UVB irradiance, but sunscreen use did not reduce sunburn episodes. It was shown that UVB-induced erythema depends on surface exposure but not irradiance of UVB. We previously showed that irradiance plays a critical role in UVB-induced cell differentiation. This study investigated the impact of irradiance on UVB-induced photocarcinogenesis. For hairless mice receiving equivalent exposure of UVB radiation, the low irradiance (LI) UVB treated mice showed more rapid tumor development, larger tumor burden, and more keratinocytes harboring mutant p53 in the epidermis as compared to their high irradiance (HI) UVB treated counterpart. Mechanistically, using cell models, we demonstrated that LI UVB radiation allowed more keratinocytes harboring DNA damages to enter cell cycle via ERK-related signaling as compared to its HI UVB counterpart. These results indicated that at equivalent exposure, UVB radiation at LI has higher photocarcinogenic potential as compared to its HI counterpart. Since erythema is the observed sunburn at moderate doses and use of sunscreen was not found to associate with reduced sunburn episodes, the biological significance of sunburn with or without sunscreen use warrants further investigation.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116611/
_version_	1613734413443530752

Irradiance-dependent UVB Photocarcinogenesis

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