Epigenetic and genetic components of height regulation

Epigenetic and genetic components of height regulation

Adult height is a highly heritable trait. Here we identified 31.6 million sequence variants by whole-genome sequencing of 8,453 Icelanders and tested them for association with adult height by imputing them into 88,835 Icelanders. Here we discovered 13 novel height associations by testing four differ...

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Main Authors: Benonisdottir, Stefania, Oddsson, Asmundur, Helgason, Agnar, Kristjansson, Ragnar P., Sveinbjornsson, Gardar, Oskarsdottir, Arna, Thorleifsson, Gudmar, Davidsson, Olafur B., Arnadottir, Gudny A., Sulem, Gerald, Jensson, Brynjar O., Holm, Hilma, Alexandersson, Kristjan F., Tryggvadottir, Laufey, Walters, G. Bragi, Gudjonsson, Sigurjon A., Ward, Lucas D., Sigurdsson, Jon K., Iordache, Paul D., Frigge, Michael L., Rafnar, Thorunn, Kong, Augustine, Masson, Gisli, Helgason, Hannes, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Sulem, Patrick, Stefansson, Kari
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116096/
id pubmed-5116096
recordtype oai_dc
spelling pubmed-51160962017-01-13 Epigenetic and genetic components of height regulation Benonisdottir, Stefania Oddsson, Asmundur Helgason, Agnar Kristjansson, Ragnar P. Sveinbjornsson, Gardar Oskarsdottir, Arna Thorleifsson, Gudmar Davidsson, Olafur B. Arnadottir, Gudny A. Sulem, Gerald Jensson, Brynjar O. Holm, Hilma Alexandersson, Kristjan F. Tryggvadottir, Laufey Walters, G. Bragi Gudjonsson, Sigurjon A. Ward, Lucas D. Sigurdsson, Jon K. Iordache, Paul D. Frigge, Michael L. Rafnar, Thorunn Kong, Augustine Masson, Gisli Helgason, Hannes Thorsteinsdottir, Unnur Gudbjartsson, Daniel F. Sulem, Patrick Stefansson, Kari Article Adult height is a highly heritable trait. Here we identified 31.6 million sequence variants by whole-genome sequencing of 8,453 Icelanders and tested them for association with adult height by imputing them into 88,835 Icelanders. Here we discovered 13 novel height associations by testing four different models including parent-of-origin (|β|=0.4–10.6 cm). The minor alleles of three parent-of-origin signals associate with less height only when inherited from the father and are located within imprinted regions (IGF2-H19 and DLK1-MEG3). We also examined the association of these sequence variants in a set of 12,645 Icelanders with birth length measurements. Two of the novel variants, (IGF2-H19 and TET1), show significant association with both adult height and birth length, indicating a role in early growth regulation. Among the parent-of-origin signals, we observed opposing parental effects raising questions about underlying mechanisms. These findings demonstrate that common variations affect human growth by parental imprinting. Nature Publishing Group 2016-11-16 /pmc/articles/PMC5116096/ /pubmed/27848971 http://dx.doi.org/10.1038/ncomms13490 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Benonisdottir, Stefania
Oddsson, Asmundur
Helgason, Agnar
Kristjansson, Ragnar P.
Sveinbjornsson, Gardar
Oskarsdottir, Arna
Thorleifsson, Gudmar
Davidsson, Olafur B.
Arnadottir, Gudny A.
Sulem, Gerald
Jensson, Brynjar O.
Holm, Hilma
Alexandersson, Kristjan F.
Tryggvadottir, Laufey
Walters, G. Bragi
Gudjonsson, Sigurjon A.
Ward, Lucas D.
Sigurdsson, Jon K.
Iordache, Paul D.
Frigge, Michael L.
Rafnar, Thorunn
Kong, Augustine
Masson, Gisli
Helgason, Hannes
Thorsteinsdottir, Unnur
Gudbjartsson, Daniel F.
Sulem, Patrick
Stefansson, Kari
spellingShingle Benonisdottir, Stefania
Oddsson, Asmundur
Helgason, Agnar
Kristjansson, Ragnar P.
Sveinbjornsson, Gardar
Oskarsdottir, Arna
Thorleifsson, Gudmar
Davidsson, Olafur B.
Arnadottir, Gudny A.
Sulem, Gerald
Jensson, Brynjar O.
Holm, Hilma
Alexandersson, Kristjan F.
Tryggvadottir, Laufey
Walters, G. Bragi
Gudjonsson, Sigurjon A.
Ward, Lucas D.
Sigurdsson, Jon K.
Iordache, Paul D.
Frigge, Michael L.
Rafnar, Thorunn
Kong, Augustine
Masson, Gisli
Helgason, Hannes
Thorsteinsdottir, Unnur
Gudbjartsson, Daniel F.
Sulem, Patrick
Stefansson, Kari
Epigenetic and genetic components of height regulation
author_facet Benonisdottir, Stefania
Oddsson, Asmundur
Helgason, Agnar
Kristjansson, Ragnar P.
Sveinbjornsson, Gardar
Oskarsdottir, Arna
Thorleifsson, Gudmar
Davidsson, Olafur B.
Arnadottir, Gudny A.
Sulem, Gerald
Jensson, Brynjar O.
Holm, Hilma
Alexandersson, Kristjan F.
Tryggvadottir, Laufey
Walters, G. Bragi
Gudjonsson, Sigurjon A.
Ward, Lucas D.
Sigurdsson, Jon K.
Iordache, Paul D.
Frigge, Michael L.
Rafnar, Thorunn
Kong, Augustine
Masson, Gisli
Helgason, Hannes
Thorsteinsdottir, Unnur
Gudbjartsson, Daniel F.
Sulem, Patrick
Stefansson, Kari
author_sort Benonisdottir, Stefania
title Epigenetic and genetic components of height regulation
title_short Epigenetic and genetic components of height regulation
title_full Epigenetic and genetic components of height regulation
title_fullStr Epigenetic and genetic components of height regulation
title_full_unstemmed Epigenetic and genetic components of height regulation
title_sort epigenetic and genetic components of height regulation
description Adult height is a highly heritable trait. Here we identified 31.6 million sequence variants by whole-genome sequencing of 8,453 Icelanders and tested them for association with adult height by imputing them into 88,835 Icelanders. Here we discovered 13 novel height associations by testing four different models including parent-of-origin (|β|=0.4–10.6 cm). The minor alleles of three parent-of-origin signals associate with less height only when inherited from the father and are located within imprinted regions (IGF2-H19 and DLK1-MEG3). We also examined the association of these sequence variants in a set of 12,645 Icelanders with birth length measurements. Two of the novel variants, (IGF2-H19 and TET1), show significant association with both adult height and birth length, indicating a role in early growth regulation. Among the parent-of-origin signals, we observed opposing parental effects raising questions about underlying mechanisms. These findings demonstrate that common variations affect human growth by parental imprinting.
publisher Nature Publishing Group
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116096/
_version_ 1613733863156088832

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