Human Papilloma Virus (HPV) Oral Prevalence in Scotland (HOPSCOTCH): A Feasibility Study in Dental Settings

The purpose of this study was to test the feasibility of undertaking a full population investigation into the prevalence, incidence, and persistence of oral Human Papilloma Virus (HPV) in Scotland via dental settings. Male and female patients aged 16–69 years were recruited by Research Nurses in 3 p...

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Main Authors:	Conway, David I., Robertson, Chris, Gray, Heather, Young, Linda, McDaid, Lisa M., Winter, Andrew J., Campbell, Christine, Pan, Jiafeng, Kavanagh, Kimberley, Kean, Sharon, Bhatia, Ramya, Cubie, Heather, Clarkson, Jan E., Bagg, Jeremy, Pollock, Kevin G., Cuschieri, Kate
Format:	Online
Language:	English
Published:	Public Library of Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115665/

id	pubmed-5115665
recordtype	oai_dc
spelling	pubmed-51156652016-12-08 Human Papilloma Virus (HPV) Oral Prevalence in Scotland (HOPSCOTCH): A Feasibility Study in Dental Settings Conway, David I. Robertson, Chris Gray, Heather Young, Linda McDaid, Lisa M. Winter, Andrew J. Campbell, Christine Pan, Jiafeng Kavanagh, Kimberley Kean, Sharon Bhatia, Ramya Cubie, Heather Clarkson, Jan E. Bagg, Jeremy Pollock, Kevin G. Cuschieri, Kate Research Article The purpose of this study was to test the feasibility of undertaking a full population investigation into the prevalence, incidence, and persistence of oral Human Papilloma Virus (HPV) in Scotland via dental settings. Male and female patients aged 16–69 years were recruited by Research Nurses in 3 primary care and dental outreach teaching centres and 2 General Dental Practices (GDPs), and by Dental Care Teams in 2 further GDPs. Participants completed a questionnaire (via an online tablet computer or paper) with socioeconomic, lifestyle, and sexual history items; and were followed up at 6-months for further questionnaire through appointment or post/online. Saline oral gargle/rinse samples, collected at baseline and follow-up, were subject to molecular HPV genotyping centrally. 1213 dental patients were approached and 402 individuals consented (participation rate 33.1%). 390 completed the baseline questionnaire and 380 provided a baseline oral specimen. Follow-up rate was 61.6% at 6 months. While recruitment was no different in Research Nurse vs Dental Care Team models the Nurse model ensured more rapid recruitment. There were relatively few missing responses in the questionnaire and high levels of disclosure of risk behaviours (99% answered some of the sexual history questions). Data linkage of participant data to routine health records including HPV vaccination data was successful with 99.1% matching. Oral rinse/gargle sample collection and subsequent HPV testing was feasible. Preliminary analyses found over 95% of samples to be valid for molecular HPV detection prevalence of oral HPV infection of 5.5% (95%CI 3.7, 8.3). It is feasible to recruit and follow-up dental patients largely representative / reflective of the wider population, suggesting it would be possible to undertake a study to investigate the prevalence, incidence, and determinants of oral HPV infection in dental settings. Public Library of Science 2016-11-18 /pmc/articles/PMC5115665/ /pubmed/27861508 http://dx.doi.org/10.1371/journal.pone.0165847 Text en © 2016 Conway et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Conway, David I. Robertson, Chris Gray, Heather Young, Linda McDaid, Lisa M. Winter, Andrew J. Campbell, Christine Pan, Jiafeng Kavanagh, Kimberley Kean, Sharon Bhatia, Ramya Cubie, Heather Clarkson, Jan E. Bagg, Jeremy Pollock, Kevin G. Cuschieri, Kate
spellingShingle	Conway, David I. Robertson, Chris Gray, Heather Young, Linda McDaid, Lisa M. Winter, Andrew J. Campbell, Christine Pan, Jiafeng Kavanagh, Kimberley Kean, Sharon Bhatia, Ramya Cubie, Heather Clarkson, Jan E. Bagg, Jeremy Pollock, Kevin G. Cuschieri, Kate Human Papilloma Virus (HPV) Oral Prevalence in Scotland (HOPSCOTCH): A Feasibility Study in Dental Settings
author_facet	Conway, David I. Robertson, Chris Gray, Heather Young, Linda McDaid, Lisa M. Winter, Andrew J. Campbell, Christine Pan, Jiafeng Kavanagh, Kimberley Kean, Sharon Bhatia, Ramya Cubie, Heather Clarkson, Jan E. Bagg, Jeremy Pollock, Kevin G. Cuschieri, Kate
author_sort	Conway, David I.
title	Human Papilloma Virus (HPV) Oral Prevalence in Scotland (HOPSCOTCH): A Feasibility Study in Dental Settings
title_short	Human Papilloma Virus (HPV) Oral Prevalence in Scotland (HOPSCOTCH): A Feasibility Study in Dental Settings
title_full	Human Papilloma Virus (HPV) Oral Prevalence in Scotland (HOPSCOTCH): A Feasibility Study in Dental Settings
title_fullStr	Human Papilloma Virus (HPV) Oral Prevalence in Scotland (HOPSCOTCH): A Feasibility Study in Dental Settings
title_full_unstemmed	Human Papilloma Virus (HPV) Oral Prevalence in Scotland (HOPSCOTCH): A Feasibility Study in Dental Settings
title_sort	human papilloma virus (hpv) oral prevalence in scotland (hopscotch): a feasibility study in dental settings
description	The purpose of this study was to test the feasibility of undertaking a full population investigation into the prevalence, incidence, and persistence of oral Human Papilloma Virus (HPV) in Scotland via dental settings. Male and female patients aged 16–69 years were recruited by Research Nurses in 3 primary care and dental outreach teaching centres and 2 General Dental Practices (GDPs), and by Dental Care Teams in 2 further GDPs. Participants completed a questionnaire (via an online tablet computer or paper) with socioeconomic, lifestyle, and sexual history items; and were followed up at 6-months for further questionnaire through appointment or post/online. Saline oral gargle/rinse samples, collected at baseline and follow-up, were subject to molecular HPV genotyping centrally. 1213 dental patients were approached and 402 individuals consented (participation rate 33.1%). 390 completed the baseline questionnaire and 380 provided a baseline oral specimen. Follow-up rate was 61.6% at 6 months. While recruitment was no different in Research Nurse vs Dental Care Team models the Nurse model ensured more rapid recruitment. There were relatively few missing responses in the questionnaire and high levels of disclosure of risk behaviours (99% answered some of the sexual history questions). Data linkage of participant data to routine health records including HPV vaccination data was successful with 99.1% matching. Oral rinse/gargle sample collection and subsequent HPV testing was feasible. Preliminary analyses found over 95% of samples to be valid for molecular HPV detection prevalence of oral HPV infection of 5.5% (95%CI 3.7, 8.3). It is feasible to recruit and follow-up dental patients largely representative / reflective of the wider population, suggesting it would be possible to undertake a study to investigate the prevalence, incidence, and determinants of oral HPV infection in dental settings.
publisher	Public Library of Science
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115665/
_version_	1613733426717786112

Human Papilloma Virus (HPV) Oral Prevalence in Scotland (HOPSCOTCH): A Feasibility Study in Dental Settings

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