Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD

Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD

The methylerythritol phosphate (MEP) pathway is an essential metabolic pathway found in malaria parasites, but absent in mammals, making it a highly attractive target for the discovery of novel and selective antimalarial therapies. Using high-throughput screening, we have identified 2-phenyl benzo[d...

Full description

Bibliographic Details
Main Authors: Price, Kathryn E., Armstrong, Christopher M., Imlay, Leah S., Hodge, Dana M., Pidathala, C., Roberts, Natalie J., Park, Jooyoung, Mikati, Marwa, Sharma, Raman, Lawrenson, Alexandre S., Tolia, Niraj H., Berry, Neil G., O’Neill, Paul M., John, Audrey R. Odom
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114681/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114681/

Similar Items