Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of β-Catenin Signaling☆

Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of β-Catenin Signaling☆

Aberrant activation of Wnt/β-catenin signaling plays a key role in the onset and development of hepatocellular carcinomas (HCC), with about half of them acquiring mutations in either CTNNB1 or AXIN1. However, it remains unclear whether these mutations impose sufficient β-catenin signaling or require...

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Bibliographic Details
Main Authors: Wang, Wenhui, Xu, Lei, Liu, Pengyu, Jairam, Kiran, Yin, Yuebang, Chen, Kan, Sprengers, Dave, Peppelenbosch, Maikel P., Pan, Qiuwei, Smits, Ron
Format: Online
Language:English
Published: Neoplasia Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110474/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110474/

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