Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection

Nabekura and Lanier demonstrate that two distinct long-lived NK cell subsets with different functional properties differentiate during mouse model of cytomegalovirus (MCMV) infection. NK cells expressing the MCMV-specific Ly49H receptor differentiated into memory NK cells and Ly49H− NK cells differe...

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Main Authors:	Nabekura, Tsukasa, Lanier, Lewis L.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110025/

id	pubmed-5110025
recordtype	oai_dc
spelling	pubmed-51100252017-05-14 Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection Nabekura, Tsukasa Lanier, Lewis L. Research Articles Nabekura and Lanier demonstrate that two distinct long-lived NK cell subsets with different functional properties differentiate during mouse model of cytomegalovirus (MCMV) infection. NK cells expressing the MCMV-specific Ly49H receptor differentiated into memory NK cells and Ly49H− NK cells differentiated into cytokine-activated NK cells. Memory NK cells show enhanced effector function, whereas cytokine-activated NK cells persisted better in an MCMV-free environment. The Rockefeller University Press 2016-11-14 /pmc/articles/PMC5110025/ /pubmed/27810928 http://dx.doi.org/10.1084/jem.20160726 Text en © 2016 Nabekura and Lanier This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Nabekura, Tsukasa Lanier, Lewis L.
spellingShingle	Nabekura, Tsukasa Lanier, Lewis L. Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection
author_facet	Nabekura, Tsukasa Lanier, Lewis L.
author_sort	Nabekura, Tsukasa
title	Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection
title_short	Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection
title_full	Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection
title_fullStr	Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection
title_full_unstemmed	Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection
title_sort	tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection
description	Nabekura and Lanier demonstrate that two distinct long-lived NK cell subsets with different functional properties differentiate during mouse model of cytomegalovirus (MCMV) infection. NK cells expressing the MCMV-specific Ly49H receptor differentiated into memory NK cells and Ly49H− NK cells differentiated into cytokine-activated NK cells. Memory NK cells show enhanced effector function, whereas cytokine-activated NK cells persisted better in an MCMV-free environment.
publisher	The Rockefeller University Press
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110025/
_version_	1613727886646181888

Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection

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