Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus

We herein present the findings of a 42-year-old woman with either adrenal pheochromocytoma or intraadrenal paraganglioma that simultaneously secreted somatostatin, thus mimicking insulin-dependent diabetes mellitus. Pheochromocytoma was clinically diagnosed based on scintigraphy, elevated catecholam...

Full description

Bibliographic Details
Main Authors:	Hirai, Hiroyuki, Midorikawa, Sanae, Suzuki, Shinichi, Sasano, Hironobu, Watanabe, Tsuyoshi, Satoh, Hiroaki
Format:	Online
Language:	English
Published:	The Japanese Society of Internal Medicine 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109567/

id	pubmed-5109567
recordtype	oai_dc
spelling	pubmed-51095672016-11-17 Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus Hirai, Hiroyuki Midorikawa, Sanae Suzuki, Shinichi Sasano, Hironobu Watanabe, Tsuyoshi Satoh, Hiroaki Case Report We herein present the findings of a 42-year-old woman with either adrenal pheochromocytoma or intraadrenal paraganglioma that simultaneously secreted somatostatin, thus mimicking insulin-dependent diabetes mellitus. Pheochromocytoma was clinically diagnosed based on scintigraphy, elevated catecholamine levels, and finally a histopathological analysis of resected specimens. The patient had diabetic ketosis, requiring 40 U insulin for treatment. Following laparoscopic adrenalectomy, insulin therapy was discontinued and the urinary c-peptide levels changed from 5.5-9.0 to 81.3-87.0 μg/day. Histologically, somatostatin immunoreactivity was detected and the somatostatin levels were elevated in the serum-like fluid obtained from the tumor. Clinicians should be aware of the possible occurrence of simultaneous ectopic hormone secretion in patients with pheochromocytoma. The Japanese Society of Internal Medicine 2016-10-15 /pmc/articles/PMC5109567/ /pubmed/27746437 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hirai, Hiroyuki Midorikawa, Sanae Suzuki, Shinichi Sasano, Hironobu Watanabe, Tsuyoshi Satoh, Hiroaki
spellingShingle	Hirai, Hiroyuki Midorikawa, Sanae Suzuki, Shinichi Sasano, Hironobu Watanabe, Tsuyoshi Satoh, Hiroaki Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus
author_facet	Hirai, Hiroyuki Midorikawa, Sanae Suzuki, Shinichi Sasano, Hironobu Watanabe, Tsuyoshi Satoh, Hiroaki
author_sort	Hirai, Hiroyuki
title	Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus
title_short	Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus
title_full	Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus
title_fullStr	Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus
title_full_unstemmed	Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus
title_sort	somatostatin-secreting pheochromocytoma mimicking insulin-dependent diabetes mellitus
description	We herein present the findings of a 42-year-old woman with either adrenal pheochromocytoma or intraadrenal paraganglioma that simultaneously secreted somatostatin, thus mimicking insulin-dependent diabetes mellitus. Pheochromocytoma was clinically diagnosed based on scintigraphy, elevated catecholamine levels, and finally a histopathological analysis of resected specimens. The patient had diabetic ketosis, requiring 40 U insulin for treatment. Following laparoscopic adrenalectomy, insulin therapy was discontinued and the urinary c-peptide levels changed from 5.5-9.0 to 81.3-87.0 μg/day. Histologically, somatostatin immunoreactivity was detected and the somatostatin levels were elevated in the serum-like fluid obtained from the tumor. Clinicians should be aware of the possible occurrence of simultaneous ectopic hormone secretion in patients with pheochromocytoma.
publisher	The Japanese Society of Internal Medicine
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109567/
_version_	1613727380553072640

Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus

Similar Items