rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk

NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3′-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the r...

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Main Authors:	Liu, Jingjing, Lončar, Ivona, Collée, J. Margriet, Bolla, Manjeet K., Dennis, Joe, Michailidou, Kyriaki, Wang, Qin, Andrulis, Irene L., Barile, Monica, Beckmann, Matthias W., Behrens, Sabine, Benitez, Javier, Blomqvist, Carl, Boeckx, Bram, Bogdanova, Natalia V., Bojesen, Stig E., Brauch, Hiltrud, Brennan, Paul, Brenner, Hermann, Broeks, Annegien, Burwinkel, Barbara, Chang-Claude, Jenny, Chen, Shou-Tung, Chenevix-Trench, Georgia, Cheng, Ching Y., Choi, Ji-Yeob, Couch, Fergus J., Cox, Angela, Cross, Simon S., Cuk, Katarina, Czene, Kamila, Dörk, Thilo, dos-Santos-Silva, Isabel, Fasching, Peter A., Figueroa, Jonine, Flyger, Henrik, García-Closas, Montserrat, Giles, Graham G., Glendon, Gord, Goldberg, Mark S., González-Neira, Anna, Guénel, Pascal, Haiman, Christopher A., Hamann, Ute, Hart, Steven N., Hartman, Mikael, Hatse, Sigrid, Hopper, John L., Ito, Hidemi, Jakubowska, Anna, Kabisch, Maria, Kang, Daehee, Kosma, Veli-Matti, Kristensen, Vessela N., Le Marchand, Loic, Lee, Eunjung, Li, Jingmei, Lophatananon, Artitaya, Jan Lubinski, Mannermaa, Arto, Matsuo, Keitaro, Milne, Roger L., Neuhausen, Susan L., Nevanlinna, Heli, Orr, Nick, Perez, Jose I. A., Peto, Julian, Putti, Thomas C., Pylkäs, Katri, Radice, Paolo, Sangrajrang, Suleeporn, Sawyer, Elinor J., Schmidt, Marjanka K., Schneeweiss, Andreas, Shen, Chen-Yang, Shrubsole, Martha J., Shu, Xiao-Ou, Simard, Jacques, Southey, Melissa C., Swerdlow, Anthony, Teo, Soo H., Tessier, Daniel C., Thanasitthichai, Somchai, Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Tseng, Chiu-Chen, Vachon, Celine, Winqvist, Robert, Wu, Anna H., Yannoukakos, Drakoulis, Zheng, Wei, Hall, Per, Dunning, Alison M., Easton, Douglas F., Hooning, Maartje J., van den Ouweland, Ans M. W., Martens, John W. M., Hollestelle, Antoinette
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109293/

id	pubmed-5109293
recordtype	oai_dc
spelling	pubmed-51092932016-11-25 rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk Liu, Jingjing Lončar, Ivona Collée, J. Margriet Bolla, Manjeet K. Dennis, Joe Michailidou, Kyriaki Wang, Qin Andrulis, Irene L. Barile, Monica Beckmann, Matthias W. Behrens, Sabine Benitez, Javier Blomqvist, Carl Boeckx, Bram Bogdanova, Natalia V. Bojesen, Stig E. Brauch, Hiltrud Brennan, Paul Brenner, Hermann Broeks, Annegien Burwinkel, Barbara Chang-Claude, Jenny Chen, Shou-Tung Chenevix-Trench, Georgia Cheng, Ching Y. Choi, Ji-Yeob Couch, Fergus J. Cox, Angela Cross, Simon S. Cuk, Katarina Czene, Kamila Dörk, Thilo dos-Santos-Silva, Isabel Fasching, Peter A. Figueroa, Jonine Flyger, Henrik García-Closas, Montserrat Giles, Graham G. Glendon, Gord Goldberg, Mark S. González-Neira, Anna Guénel, Pascal Haiman, Christopher A. Hamann, Ute Hart, Steven N. Hartman, Mikael Hatse, Sigrid Hopper, John L. Ito, Hidemi Jakubowska, Anna Kabisch, Maria Kang, Daehee Kosma, Veli-Matti Kristensen, Vessela N. Le Marchand, Loic Lee, Eunjung Li, Jingmei Lophatananon, Artitaya Jan Lubinski, Mannermaa, Arto Matsuo, Keitaro Milne, Roger L. Neuhausen, Susan L. Nevanlinna, Heli Orr, Nick Perez, Jose I. A. Peto, Julian Putti, Thomas C. Pylkäs, Katri Radice, Paolo Sangrajrang, Suleeporn Sawyer, Elinor J. Schmidt, Marjanka K. Schneeweiss, Andreas Shen, Chen-Yang Shrubsole, Martha J. Shu, Xiao-Ou Simard, Jacques Southey, Melissa C. Swerdlow, Anthony Teo, Soo H. Tessier, Daniel C. Thanasitthichai, Somchai Tomlinson, Ian Torres, Diana Truong, Thérèse Tseng, Chiu-Chen Vachon, Celine Winqvist, Robert Wu, Anna H. Yannoukakos, Drakoulis Zheng, Wei Hall, Per Dunning, Alison M. Easton, Douglas F. Hooning, Maartje J. van den Ouweland, Ans M. W. Martens, John W. M. Hollestelle, Antoinette Article NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3′-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936–1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r2 > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969–1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905–1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility. Nature Publishing Group 2016-11-15 /pmc/articles/PMC5109293/ /pubmed/27845421 http://dx.doi.org/10.1038/srep36874 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Liu, Jingjing Lončar, Ivona Collée, J. Margriet Bolla, Manjeet K. Dennis, Joe Michailidou, Kyriaki Wang, Qin Andrulis, Irene L. Barile, Monica Beckmann, Matthias W. Behrens, Sabine Benitez, Javier Blomqvist, Carl Boeckx, Bram Bogdanova, Natalia V. Bojesen, Stig E. Brauch, Hiltrud Brennan, Paul Brenner, Hermann Broeks, Annegien Burwinkel, Barbara Chang-Claude, Jenny Chen, Shou-Tung Chenevix-Trench, Georgia Cheng, Ching Y. Choi, Ji-Yeob Couch, Fergus J. Cox, Angela Cross, Simon S. Cuk, Katarina Czene, Kamila Dörk, Thilo dos-Santos-Silva, Isabel Fasching, Peter A. Figueroa, Jonine Flyger, Henrik García-Closas, Montserrat Giles, Graham G. Glendon, Gord Goldberg, Mark S. González-Neira, Anna Guénel, Pascal Haiman, Christopher A. Hamann, Ute Hart, Steven N. Hartman, Mikael Hatse, Sigrid Hopper, John L. Ito, Hidemi Jakubowska, Anna Kabisch, Maria Kang, Daehee Kosma, Veli-Matti Kristensen, Vessela N. Le Marchand, Loic Lee, Eunjung Li, Jingmei Lophatananon, Artitaya Jan Lubinski, Mannermaa, Arto Matsuo, Keitaro Milne, Roger L. Neuhausen, Susan L. Nevanlinna, Heli Orr, Nick Perez, Jose I. A. Peto, Julian Putti, Thomas C. Pylkäs, Katri Radice, Paolo Sangrajrang, Suleeporn Sawyer, Elinor J. Schmidt, Marjanka K. Schneeweiss, Andreas Shen, Chen-Yang Shrubsole, Martha J. Shu, Xiao-Ou Simard, Jacques Southey, Melissa C. Swerdlow, Anthony Teo, Soo H. Tessier, Daniel C. Thanasitthichai, Somchai Tomlinson, Ian Torres, Diana Truong, Thérèse Tseng, Chiu-Chen Vachon, Celine Winqvist, Robert Wu, Anna H. Yannoukakos, Drakoulis Zheng, Wei Hall, Per Dunning, Alison M. Easton, Douglas F. Hooning, Maartje J. van den Ouweland, Ans M. W. Martens, John W. M. Hollestelle, Antoinette
spellingShingle	Liu, Jingjing Lončar, Ivona Collée, J. Margriet Bolla, Manjeet K. Dennis, Joe Michailidou, Kyriaki Wang, Qin Andrulis, Irene L. Barile, Monica Beckmann, Matthias W. Behrens, Sabine Benitez, Javier Blomqvist, Carl Boeckx, Bram Bogdanova, Natalia V. Bojesen, Stig E. Brauch, Hiltrud Brennan, Paul Brenner, Hermann Broeks, Annegien Burwinkel, Barbara Chang-Claude, Jenny Chen, Shou-Tung Chenevix-Trench, Georgia Cheng, Ching Y. Choi, Ji-Yeob Couch, Fergus J. Cox, Angela Cross, Simon S. Cuk, Katarina Czene, Kamila Dörk, Thilo dos-Santos-Silva, Isabel Fasching, Peter A. Figueroa, Jonine Flyger, Henrik García-Closas, Montserrat Giles, Graham G. Glendon, Gord Goldberg, Mark S. González-Neira, Anna Guénel, Pascal Haiman, Christopher A. Hamann, Ute Hart, Steven N. Hartman, Mikael Hatse, Sigrid Hopper, John L. Ito, Hidemi Jakubowska, Anna Kabisch, Maria Kang, Daehee Kosma, Veli-Matti Kristensen, Vessela N. Le Marchand, Loic Lee, Eunjung Li, Jingmei Lophatananon, Artitaya Jan Lubinski, Mannermaa, Arto Matsuo, Keitaro Milne, Roger L. Neuhausen, Susan L. Nevanlinna, Heli Orr, Nick Perez, Jose I. A. Peto, Julian Putti, Thomas C. Pylkäs, Katri Radice, Paolo Sangrajrang, Suleeporn Sawyer, Elinor J. Schmidt, Marjanka K. Schneeweiss, Andreas Shen, Chen-Yang Shrubsole, Martha J. Shu, Xiao-Ou Simard, Jacques Southey, Melissa C. Swerdlow, Anthony Teo, Soo H. Tessier, Daniel C. Thanasitthichai, Somchai Tomlinson, Ian Torres, Diana Truong, Thérèse Tseng, Chiu-Chen Vachon, Celine Winqvist, Robert Wu, Anna H. Yannoukakos, Drakoulis Zheng, Wei Hall, Per Dunning, Alison M. Easton, Douglas F. Hooning, Maartje J. van den Ouweland, Ans M. W. Martens, John W. M. Hollestelle, Antoinette rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk
author_facet	Liu, Jingjing Lončar, Ivona Collée, J. Margriet Bolla, Manjeet K. Dennis, Joe Michailidou, Kyriaki Wang, Qin Andrulis, Irene L. Barile, Monica Beckmann, Matthias W. Behrens, Sabine Benitez, Javier Blomqvist, Carl Boeckx, Bram Bogdanova, Natalia V. Bojesen, Stig E. Brauch, Hiltrud Brennan, Paul Brenner, Hermann Broeks, Annegien Burwinkel, Barbara Chang-Claude, Jenny Chen, Shou-Tung Chenevix-Trench, Georgia Cheng, Ching Y. Choi, Ji-Yeob Couch, Fergus J. Cox, Angela Cross, Simon S. Cuk, Katarina Czene, Kamila Dörk, Thilo dos-Santos-Silva, Isabel Fasching, Peter A. Figueroa, Jonine Flyger, Henrik García-Closas, Montserrat Giles, Graham G. Glendon, Gord Goldberg, Mark S. González-Neira, Anna Guénel, Pascal Haiman, Christopher A. Hamann, Ute Hart, Steven N. Hartman, Mikael Hatse, Sigrid Hopper, John L. Ito, Hidemi Jakubowska, Anna Kabisch, Maria Kang, Daehee Kosma, Veli-Matti Kristensen, Vessela N. Le Marchand, Loic Lee, Eunjung Li, Jingmei Lophatananon, Artitaya Jan Lubinski, Mannermaa, Arto Matsuo, Keitaro Milne, Roger L. Neuhausen, Susan L. Nevanlinna, Heli Orr, Nick Perez, Jose I. A. Peto, Julian Putti, Thomas C. Pylkäs, Katri Radice, Paolo Sangrajrang, Suleeporn Sawyer, Elinor J. Schmidt, Marjanka K. Schneeweiss, Andreas Shen, Chen-Yang Shrubsole, Martha J. Shu, Xiao-Ou Simard, Jacques Southey, Melissa C. Swerdlow, Anthony Teo, Soo H. Tessier, Daniel C. Thanasitthichai, Somchai Tomlinson, Ian Torres, Diana Truong, Thérèse Tseng, Chiu-Chen Vachon, Celine Winqvist, Robert Wu, Anna H. Yannoukakos, Drakoulis Zheng, Wei Hall, Per Dunning, Alison M. Easton, Douglas F. Hooning, Maartje J. van den Ouweland, Ans M. W. Martens, John W. M. Hollestelle, Antoinette
author_sort	Liu, Jingjing
title	rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk
title_short	rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk
title_full	rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk
title_fullStr	rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk
title_full_unstemmed	rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk
title_sort	rs2735383, located at a microrna binding site in the 3’utr of nbs1, is not associated with breast cancer risk
description	NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3′-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936–1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r2 > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969–1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905–1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109293/
_version_	1613726996505821184

rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk

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