Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways

Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways

Hepatocellular carcinoma (HCC) is refractory to chemotherapies, necessitating novel effective agents. The lysosome inhibitor Bafilomycin A1 (BafA1) at high concentrations displays cytotoxicity in a variety of cancers. Here we show that BafA1 at nanomolar concentrations suppresses HCC cell growth in...

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Bibliographic Details
Main Authors: Yan, Yumei, Jiang, Ke, Liu, Peng, Zhang, Xianbin, Dong, Xin, Gao, Jingchun, Liu, Quentin, Barr, Martin P., Zhang, Quan, Hou, Xiukun, Meng, Songshu, Gong, Peng
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109251/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109251/

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